Immune System 2 Flashcards
What is blood composed of?
Plasma, proteins including antibodies.
Other solutes
Water
Immune cells such as platelets pin white blood cells and red blood cells.
What is the function of Immune cells in blood?
Platelets - blood clotting
Red blood cells - oxygenating the body
White blood cells- cells of immune system, constantly circulating and protecting from infection
What is the role of bone marrow?
Bone marrow stem cells = source of blood cells.
What does the myeloid blood cell lineage develop into?
Cells associated with the innate immune system… granulocytes, monocytes, dendritic cells, platelets
What to lymphoid cell lineages develop into.
B and T lymphocytes (adaptive immune cells)
Where do cell lineages come from ?
White blood cells that develop and arise from the stem cells in the bone marrow.
What are neutrophils?
Myeloid granulocyte, majority of white blood cells. They are highly phagocytes and numbers increase during infection and can move into tissue during inflammation.
What are Mast cells?
Myeloid granulocytes only found in tissues. Line mucosal surfaces and secrete granules that attract other white blood cells to areas of damage or infection.
List phagocytic cells
Monocytes
Macrophages
Dendritic cells
Functions of macrophages ?
Can become resident or move through tissue.
Phagocytosis
Release of chemical messengers
Show information about pathogenic microbes to T cells
Role of dendritic cells.
Triggers an adaptive immune response.
Phagocytic
Display pathogens to T cells
How do cells of the immune system move around the body?
Cells carried in blood and lymph
Can leave blood to enter tissue
Lymph in tissue collects into lymphatic vesicles
These drain lymph into lymph nodes
What are PAMPS ?
Pathogen associated molecular patterns
How do innate cells recognise pathogens.
Using toll like receptors, pattern recognition receptors will bind PAMPS then send signal down to the nucleus of cell telling the cell to upregulate gene transcription and make proteins that can fight infection
How is fever induced?
re setting of thermostat in hypothalamus, caused by pyrogens released by cells of the immune system.
