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USMLE > Immune-Pharm > Flashcards

Immune-Pharm Flashcards

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USMLE® Step 1 flashcards
1
Q

Cyclosporine

A

Binds cyclophilins, inhibits calcineurin, inhibiting IL-2 production; post organ transplant; nephrotoxicity (use mannitol), gout

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2
Q

Tacrolimus

A

Binds FK also resulting in inhibition of calcineurin and reduces IL-2 and other cytokine secretion; for organ transplants etc.; Nephrotoxicity, neuropathy, HTN, hyperglycemia

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3
Q

Sacrolimus

A

inhibits mTOR and reduces response to IL-2; Hyperlipidemia, thrombocytopenia, leukopenia

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4
Q

Daclizumab

A

Monclonal antibody against IL-2 recepotr

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5
Q

Drugs affecting IL-2

A

Cyclosporine, daclizumab, tacrolimus, sacrolimus

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6
Q

Azathioprine

A

antimetabolite precursor of 6-mercaptopurine, inhibits purine synthesis, toxic buildup in lymph cells; Kidney transplantation; xanthin oxidase metabolizes, don’t give with allopurinol

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7
Q

Muromonab

A

Anti-CD3 on T cells (CD3 is responsible for signal transduction); Kidney transplant; cytokine release syndrome

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8
Q

Aldesleukin

A

IL-2 analog; for renal cell carcinoma, melanoma

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9
Q

Epo

A

anemias dealing with renal failure

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10
Q

Filgrastim

A

Granulocyte colony stimulating factor

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11
Q

Sargramostim

A

Granulocyte-macrophage colony stimulating factor

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12
Q

alpha-IFN

A

IFN-alpha; for Hepatitis B and C, Kaposi’s sarcoma, leukemias, malignant

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13
Q

beta-IFN

A

For Multiple sclerosis

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14
Q

Gamma-IFN

A

Chronic granulomatos disease

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15
Q

Oprelvekin

A

IL-11 analog; for Thrombocytopenia

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16
Q

Thrombopoietin

A

For thrombocytopenia

17
Q

Infliximab

A

monoclonal antibody against TNF-alpha; for Crohn’s disease, RA, psoriatic arthritis

18
Q

Etanercept

A

TNF-alpha target; for same as infliximab

19
Q

Adalimumab

A

TNF-alpha; same as infliximab

20
Q

Abciximab

A

GpbIIb/IIIa; prevent cardiac ischemia in unstable angina and in patients treated with precutaneous coronary intervention

21
Q

Trastuzumab

A

erb-B2; HER-2 overexpressing breast cancer

22
Q

Rituximab

A

CD20; Non-hodgkin’s lymphoma

23
Q

Omalizumab

A

IgE; additional line of treatment for severe asthma attacks

24
Q

Mycophenolate Mofetil

A

Inhibits de novo synthesis of purines by inhibiting inosine monophosphate dehydrogenase; major teratogen

25
Q

Prednisone

A

decreases prostaglandin production due to inhibition of PL-A2 and COX-2 downregulation

26
Q

Thalidomide

A

sedative has teratogenic and immunosuppressant actions; useful for Hansen’s disease, MM and cancer

USMLE (14 decks)

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