Immune-Mediated Hemolytic Anemia (IMHA)

Question 1

Is oxygen indicated for IMHA?

Answer 1

No

Question 2

3 tests used to identify IMHA

Answer 2

1) Positive Coombs
2) Agglutination
3) Spherocytes

Question 3

2 signs of intravascular hemolysis

Answer 3

Hemoglobinuria + Icterus

Question 4

3 Therapeutic Goals of IMHA

Answer 4

1) Specific
2) Supportive
3) Symptomatic

Question 5

Target for Prednisone

Answer 5

Inhibits both T and B cell as well as inhibit antibody recognition from macrophages in the spleen

Question 6

3 Clinical presentations of IMHA

Answer 6

1) Icterus
2) Splenomegaly/hepatomegaly
3) Discolored urine/stool

Question 7

Target for Mycophenolate

Answer 7

Affects both T and B cells, replacement/substitute for azathioprine

Question 8

First steps of IMHA (5 things)

Answer 8

1) Recognize anemia (clincial presentation)
2) Predict the underlying mechanism
3) Estimate the degree of chronicity
4) Confirm the diagnosis
5) Determine the underlying cause

Question 9

What is IMHA?

Answer 9

Disease in which antibodies are directed at antigens expressed on the surface of erythrocytes promoting their accelerated destruction

Question 10

Target for Azathioprine

Answer 10

Affects T cells to prevent antibody production

Question 11

What category does IMHA fall under

Answer 11

Anemia -> Regenerative -> Destruction/Hemolysis

Question 12

2 things Schistocytes are indicators for

Answer 12

1) DIC
2) Hemangiosarcoma

Question 13

Sign of Extravascular hemolysis

Answer 13

Icterus

Question 14

Mortality rates for canine IMHA

Answer 14

30-70%