Disorders of Hemostasis and Hematologic Diseases

Question 1

_____ assesses intrinsic pathway

Answer 1

PTT

Question 2

Acute management of IMTP of an unstable patient

Answer 2

Blood transfusion with RBC’s

-only if there is a marked concurrent anemia (PCV <12%)

Question 3

5 actions of glucocorticoids at immunosuppressive doses

Answer 3

1) Downregulate Fc receptor expression on macs
2) Decrease Ig affinity for RBC
3) Suppress T cell function
4) Induce apoptosis of T cells
5) B cell Ab production may be inhibited

All results to decreased phagocytosis

Question 4

_____ assesses the common pathway

Answer 4

Fibrinogen

Question 5

2 tests used to screen for malignancy

Answer 5

1) Bone marrow aspirate/core biopsy
2) Imaging (thoracic rads, abdominal ultrasound)

Question 6

2 causes of Thrombocytopenia

Answer 6

1) Not generating enough
- Bone marrow disease (mild to severe)
2) Leaving circulation too quickly
- Consumption (DIC) (mild to severe)
- Destruction/immune mediated (severe)

Question 7

Mechanism of Action for Human IVIG

Answer 7

Temporary blockade of Fc receptors of phagocytes

Question 8

______ assesses extrinsic pathway

Answer 8

PT

Question 9

Acute management of IMTP with normal PCV

Answer 9

1) Doxycycline
2) Prednisone
3) Cage rest
4) No jugular venipuncture
5) Monitor PCV twice daily and platelet count every 1-2 days

Question 10

How to confirm diagnosis for Erlichia canis?

Answer 10

Serology for tick panel with 4 fold increase

Question 11

4 main treatments for IMTP therapy

Answer 11

1) Glucocorticoids
2) Vincristine
3) Azathioprine
4) Cyclosporine

Question 12

Diagnosis for bone marrow disease

Answer 12

Bone marrow sampling

Question 13

Test used to screen for SLE (lupus)

Answer 13

Antinuclear Antibody

Question 14

Test that occassionally will see concurrent ITP with IMHA

Answer 14

Coombs test

Question 15

Petechia and Ecchymosis

Primary or Secondary Hemastasis defect?

Answer 15

Primary Hemostasis defect

Question 16

Normal buccal mucosa bleeding time (BMBT)

in canines -> ?

in felines -> ?

Answer 16

in canines -> <3.5 mins

in felines -> <2.5 mins

Question 17

What does positive test of a Snap 4Dx Test tell you?

Answer 17

Positive test indicates exposure, NOT infection

Question 18

Which coagulation factor has the shortest half life

Answer 18

Factor 7 (VII)

Question 19

Mechanism of action for Mycophenolate mofetil

Answer 19

Inhibits inosine-5’-monophosphate dehydrogenase; high levels in activated lymphocytes

-leads to depletion of guanosine

Question 20

Mechanism of Action of Vincristine

Answer 20

Premature release of platelets from marrow

Question 21

4 Vitamin K dependent coagulation factors

Answer 21

2 , 7 , 9 , 10

II , XII , IX , X