Chemotherapy 1

Question 1

3 breeds affected by the MDR1 mutation

Answer 1

1) Australian shepherd
2) Collie
3) Long-hair Whippet

Question 2

2 High Risk Drug combos for MDR1 mutation dog breeds

Answer 2

1) Vincristine & Vinblastine
2) Doxorubicin & Mitoxantrone

Question 3

Site of Action for L-asparaginase and Vinca alkaloids

Answer 3

Microtubules

Question 4

Once the tumor has reached ______ cells, it is likely that chemotherapy resistant cells have developed due to mutations

Answer 4

1 million cells

Question 5

3 sites of rapidly dividing tissue affected by chemotherapy toxicity

Answer 5

1) Bone marrow
2) Hair follicles (alopecia)
3) GI tract

think “BAG”

Question 6

When is diarrhea seen after chemotherapy in most cases?

Answer 6

3-5 days after chemotherapy

Question 7

5 Indications for Chemotherapy

Answer 7

1) Patients with measurable tumor known to be senstive to chemotherapy
2) Adjuvant therapy to suppress occult micrometasis after local therapy
3) Palliate unresectable or metastatic cancer
4) Occasionally, to downstage/reduce a chemosensitive tumor before definitive therapy
5) Occasionally, to sensitize tissues to radiation

Question 8

Cell count considered for no myelosuppressive chemotherapy

Answer 8

<2,000 cells/uL WBC or platelet <75,000/uL

Question 9

Chemotherapy safety for Vet staff (5 things)

Answer 9

1) Drugs must be stored in secure place & clearly labeled
2) No drinks, food, etc in chemo area
3) Drugs should be handled in biosafety cabinet (chemical hood)
4) When preparing drugs, wear masks, gloves, gown/smock
5) Prevent aerosolization

Question 10

First anticancer agent used in people in the ‘40’s

Answer 10

Mechlorethamine

Question 11

Dobies with cardiomyopathy should avoid _______

Answer 11

Doxorubicin

Question 12

Geriatric cats with CRF should avoid/reduce __________

Answer 12

Doxorubicin

Question 13

Site of Action for Alkylating agents, Alkylating like agents, and antibiotics

Answer 13

DNA