Hematopoietic Malignancies 1 Flashcards
Clinical presentation of Canine Lymphoma
Multicenteric -> 80% of lymphoma cases
Generalized, painless lymphadenopathy
Treatment for Low Grade Lymphoma
Prednisone and/or Chlorambucil
Where is the most common anatomic location for lymphoma?
Gastrointestinal lymphoma
Diagnostic test considered as Gold Standard for Lymphoma
Lymph node biopsy
Epidemiology of Canine Lymphoma
~80% of all hematopoietic tumors
1/4 of all canine cancer
Increases with age
Diagnostic test to determine between low grade and high grade
Cytology
Cytologic evaluation of Lymphoma
>50% large lymphocytes or lymphoblasts
-> intermediate to high grade lymphoma
Treatment for Colonic Lymphoma
Surgical biopsy/mass removal
Lymphoid cell populations change rapidly after even a single dose of prednisone/other steroid
True or False?
True
Tissue Subtypes:
B cell lymphoid cancers -> ?
T cell/NK lymphoid cancers -> ?
B cell lymphoid cancers -> Diffuse Large B Cell LSA/High Grade B Cell
T cell/NK lymphoid cancers -> Peripheral T Cell Lymphoma (NOS)
(NOS= not otherwise specified)
Treatment for Lymphocytic LSA
Prednisone +/- Chlorambucil
Resist Criteria for Remission:
- complete response -> ?
- partial response -> ?
- stable disease -> ?
- progressive disease -> ?
- complete response -> normal palpation/imaging
- partial response -> >30% reduction
- stable disease -> not partial response/not progressive disease
- progressive disease -> >20% increase
What type of patient has the highest risk for feline lymphoma?
FelV patients
Most common immunohistochemistry of Lymphocytic GI lymphoma
Monoclonal population, most commonly T cell
Diagnostic test to determine between B cell and T cell tumors
PCR
