Hematopoietic Malignancies 1

Question 1

Clinical presentation of Canine Lymphoma

Answer 1

Multicenteric -> 80% of lymphoma cases

Generalized, painless lymphadenopathy

Question 2

Treatment for Low Grade Lymphoma

Answer 2

Prednisone and/or Chlorambucil

Question 3

Where is the most common anatomic location for lymphoma?

Answer 3

Gastrointestinal lymphoma

Question 4

Diagnostic test considered as Gold Standard for Lymphoma

Answer 4

Lymph node biopsy

Question 5

Epidemiology of Canine Lymphoma

Answer 5

~80% of all hematopoietic tumors

1/4 of all canine cancer

Increases with age

Question 6

Diagnostic test to determine between low grade and high grade

Answer 6

Cytology

Question 7

Cytologic evaluation of Lymphoma

Answer 7

>50% large lymphocytes or lymphoblasts

-> intermediate to high grade lymphoma

Question 8

Treatment for Colonic Lymphoma

Answer 8

Surgical biopsy/mass removal

Question 9

Lymphoid cell populations change rapidly after even a single dose of prednisone/other steroid

True or False?

Answer 9

True

Question 10

Tissue Subtypes:

B cell lymphoid cancers -> ?

T cell/NK lymphoid cancers -> ?

Answer 10

B cell lymphoid cancers -> Diffuse Large B Cell LSA/High Grade B Cell

T cell/NK lymphoid cancers -> Peripheral T Cell Lymphoma (NOS)

(NOS= not otherwise specified)

Question 11

Treatment for Lymphocytic LSA

Answer 11

Prednisone +/- Chlorambucil

Question 12

Resist Criteria for Remission:

• complete response -> ?
• partial response -> ?
• stable disease -> ?
• progressive disease -> ?

Answer 12

• complete response -> normal palpation/imaging
• partial response -> >30% reduction
• stable disease -> not partial response/not progressive disease
• progressive disease -> >20% increase

Question 13

What type of patient has the highest risk for feline lymphoma?

Answer 13

FelV patients

Question 14

Most common immunohistochemistry of Lymphocytic GI lymphoma

Answer 14

Monoclonal population, most commonly T cell

Question 15

Diagnostic test to determine between B cell and T cell tumors

Answer 15

PCR

Question 16

Treatment for Multicentric Lymphoblastic LSA

Answer 16

CHOP based protocol

Median response duration -> 6 months

Question 17

Main 2 breed disposition of Canine Lymphoma

Answer 17

1) Boxers
2) Goldens

Question 18

Type of based protocol for high grade LSA (Grade 3 and 4) and 80-90% response

Answer 18

CHOP

Cyclophosphamide

Hydroxydaunorubicin (Doxorubicin)

Oncovin (Vincristine)

Prednisone

Question 19

Chemotherapy drug that is the strongest single agent with a higher response and longer duration

Answer 19

Doxorubicin

Question 20

_______ often associated with T cell lymphoma

Answer 20

Hypercalcemia

Question 21

What does new methylene blue stain?

Answer 21

DNA