Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BIOM3200 > Immune > Flashcards

Immune Flashcards

1
Q

3 functions of the circulatory system

A
  • transport
  • regulation
  • protection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where does erythropoiesis occur?

A
  • bone marrow
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the role of cytokine in hematopoiesis?

A
  • helps them move

- erythropoietin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How does a normoblast become a reticulocyte?

A
  • nucleus expelled once the nucleus is expressed
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the originating cells of erythropoieis and leukopoiesis?

A

uncommited stem cells in the bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Platelets are in the circulation as ___ are in the bone marrow?

A

megakaryocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What two leukocytes come from the same progenitor cell?

A

neutrophils and monocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What leukocyte is derived from its own lineage?

A

lymphocytes

from lymphocyte stem cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Bone marrow is the major hematopoetic organ after birth as the ___ is the to hematopoietic organ of the fetus

A

liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the components of hematocrit?

A
  • blood plasma
  • buffy coat
  • formed elements RBC
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the buffy coat of hematocrit?

A
  • WBC

- platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the definition of hematocrit?

A

& total volume packed in RBC.

- varies based on sex and identifies anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What gives RBCs the red colour?

A

hemoglobin

- 4 globin proeins (a2b2) and heme group that binds Fe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the blood plasma mostly composed of?

A
  • water
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What organic molecules are found in blood plasma?

A

7% of plasma

  • proteins (fibrinogen, globulins, albumins)
  • a.a
  • glucose
  • lipids
  • N wastes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Of the organic molecules that take up 7% of the blood plasma, what is the largest component?

A
  • albumin (60-80%)
17
Q

What is the function of albumin?

A
  • maintains osmotic pressure needed
    to draw water from surroundings
    to capillaries
18
Q

What is the role of globulins?

A

a and b globulins transport lipids and fat soluble vitamins

gamma globulins are antibodies

19
Q

What is theseus’ paradox?

A

if you remove all components and replace piece by piece, is it the same thing?
what happens if you take the orginal and make a second ship, is it the original?
- man or microbe ( we have 10:1 ratio of microbes)

20
Q

In regards to the complement pathway, what do antibodies do?

A
  • target pathogenic bacteria

for immunological attack

21
Q

What attacks marked pathogenic bacteria?

A
  • antibodies marked bacteria
  • innate immune cells attack
  • or
    attacked by complement (blood protein defense system)
22
Q

What is the complement pathway?

A
  • 9 complement proteins C1- C9
  • inactive in the plasma
  • activated when antibodies mark the antigens
23
Q

What are the 3 complement pathways?

A
  • classical
  • alternative
  • lectin
24
Q

What is the difference between the classical and lectin pathway?

A
  • very similar except with what they start with
    Classical: Abs and C1 binding on pathogen surrface
    -Lectin:
    lectins binding mannose residues on pathogen surface
25
Q

What is the difference between complement cascade of the classical and alternative pathway?

A
  • high levels of activity TRIGGERED by antibody

- low level continuously active IDLING

26
Q

The complement cascade is a type of ___ immunity and ___ immunity. How?

A
  • innate humoral : ready to go

- adaptive : specialized to pathogens that arent supposed to be there

27
Q

What is the result of a complement system triggered?

A
  • proteases cleave specific protein
  • amplifying cascade
  • further cleavage
28
Q

What is the end result of the complement cascade?

A
  • massive amplification of the response

- formation of MAC

29
Q

what is MAC?

A
  • membrane attack complex
  • formation as a result of the complement cascade
  • C5-9
  • kills cells
  • loss of stability
  • inserts into the membrane forms a hole so water and sodium ion permeable and cell lysis

BIOM3200 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions