IM HemOnc - Rd 2 Flashcards

1
Q

What is the Gold standard test to diagnose HIT?

A

Serotonin release assay

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3
Q

Empiric anticoagulation should only be started in what setting of a blood clot?

A

PE

NOT a DVT w/no symptoms of PE

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4
Q

Lupus anticoagulant (anti-phospholipid Ab) presents w/what lab abnormality?

A

Prolonged PTT

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5
Q

Treatment for TTP?

A

Plasma exchange

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6
Q

Middle-aged Pt that has hemolysis, cytopenias, and hypercoaguable state (portal vein thrombosis) has what?

A

PNH

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9
Q

Pt with blanching ruby-colored papules on the lips, unremitting epistaxis, increased Hct, has what?

A

AV shunting d/t Osler-Weber-Rendu (hereditary telangiectasia)

AD

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11
Q

Pt with mild hypercalcemia in the setting of metastatic breast cancer should be treated how?

A

Bisphosphonates

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13
Q

Pt that has blood transfusion and then develops DIC is d/t what etiology?

A

Acute hemolytic transfusion d/t ABO incompatibility

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14
Q

HIT can cause what unexpected problem?

A

Arterial thrombosis

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16
Q

OSA causes transient periods of hypoxia, what is the result?

A

Increased EPO

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18
Q

How do you diagnose CLL?

Shows what?

A

Flow cytometry

Clonalality of mature B cells

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19
Q

Pt that has ESRD, retinal hemorrhages, HA, and Very high HTN, what is going on?

D/t what?

A

HTN crisis

SE of EPO therapy

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22
Q

Pt that has unexplained ITP after all else has been ruled out, what else must you consider?

A

HIV

HepC

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25
Q

vWF deficiency presents w/what lab values?

A

Prolonged bleeding time

Inc PTT

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28
Q

What is a hemoglobinopathy?

A

Sickle cell or thalassemia

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29
Q

Anemia in old man that has arthritis most likely has what?

A

Fe deficiency anemia 2/2 chronic NSAID use and GI Bleed

30
Q

What is the mechanism of pancytopenia in SLE?

A

Peripheral immune-mediated destruction

31
Q

What presents w/HTN, transient vision disturbances, aquagenic pruritus, facial plethora and splenomegaly?

Treat how?

A

Polycythemia Vera

Serial phlebotomy
Also can add Hydroxyurea

34
Q

Tumor lysis syndrome presents how with the following electrolytes?

Ca
PO4
K+

WHY?

A

Dec
Inc
Inc

Cell contents are freed when cell dies and PO4 and K+ are high INTRACELLULARLY, thus when they are released Ca binds PO4 and becomes LOW

35
Q

Pt that presents w/HA, N, dizziness and polycythemia most likely has what?

Look out for what?

A

Chronic CO poisoning

Environmental work exposure

36
Q

Anemia of lymphoproliferative disorders is d/t what?

A

Bone marrow infiltration w/cancerous cells

37
Q

GVHD involves activation of what cells?

A

Donor T lymphocytes

40
Q

Pt that has fatigue and dyspnea following a respiratory infection treated w/Amoxicillin that has anemia and reticulocytosis has what?

Treatment?

A

Autoimmune hemolytic anemia —> warm agglutination

High dose glucocorticoids

42
Q

Hereditary Spherocytosis presents how?

At increased risk for what?

Lab studies show what?

A

Hemolytic anemia, jaundice, splenomegaly

Bilirubin gallstones, Parvo B19

high MCHC, high RDW

45
Q

Pt that is acutely ill and has underlying liver disease has an increased risk of developing what in as little as 7-10 days?

What lab values?

A

Vit K deficiency

Inc PT and PTT

48
Q

What presents w/progressive fatigability and lab studies that show increased Iron?

A

Sideroblastic anemia