IHL I - Leukocyte Migration

Question 0

recruitment

Answer 0

movement of leukocyte through blood into the tissues

Question 1

leukocyte homing

Answer 1

movement of leukocyte to a particular type of tissue

Question 2

when do leukocytes move to tissue?

Answer 2

when they are activated

Question 3

inflammation

Answer 3

recruitment of leukocytes and plasma proteins from the blood to sites of infection

Question 4

selectins

Answer 4

plasma membrane carbohydrate-binding adhesion molecules

initial low affinity binding

Question 5

P selectin

Answer 5

expressed on endothelial cells
-in response to microbial products, cytokines, histamine, and thrombin

rapid expression

Question 6

E selectin

Answer 6

expressed on endothelial cells
-in response to IL-1 and TNF and LPS

slower expression (1-2 hours)

Question 7

L selectin

Answer 7

expressed on leukocytes

ligand is sialomucins on the HEVs of lymph nodes

Question 8

integrins

Answer 8

allow for higher affinity binding to leukocytes and endothelial

in response to chemokines

- higher affinity of leukocyte integrins
- membrane clustering of integrins

Question 9

VLA-4

Answer 9

integrin on leukocytes

binds to VCAM on endothelial

Question 10

LFA-1

Answer 10

integrin on leukocytes

binds to ICAM-1 on endothelial

Question 11

chemokines

Answer 11

stimulate leukocyte movement into tissues

secretion induced by TNF and IL-1

have GPCRs

Question 12

CXCL8

Answer 12

IL-8

stimulates neutrophil migration and phagocytotis

Question 13

CCL2

Answer 13

chemokine

recruits monocytes, memory T cells, and dendritic cells

Question 14

CCL7

Answer 14

chemokine

attracts monocytes