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1
Q

Which Abx are time dependent?

A

Beta-lactams

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2
Q

Which Abx are concentration-dependent?

A

Aminoglycosides, quinolones, dapto

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3
Q

MOA of macrolides?

A

Binds to 50s

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4
Q

BBW of aminoglycosides?

A

Nephro, oto, and neurotoxicity

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5
Q

Aztreonam covers gram (positive/negative)

A

Negative

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6
Q

Does Aztreonam cover MRSA?

A

No

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7
Q

Does Aztreonam cover Pseudo

A

Yes

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8
Q

Which carbapenem covers for MRSA?

A

None

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9
Q

Which carbapenem covers for Pseudo?

A

All but Ertapenem

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10
Q

Which cephalosporin covers for Pseudo?

A

Cefepime (4th gen) and Ceftazidime (3rd gen)

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11
Q

What is the only beta-lactam that covers for MRSA?

A

Ceftaroline

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12
Q

Aminoglycosides cover for gram (positive/negative)

A

Negative, unless they are used in synergy with beta-lactam or vanco

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13
Q

What are the respiratory quinolones?

A

MLG

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14
Q

Which quinolones cover for Pseudo?

A

Cipro + levo

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15
Q

Which quinolone covers for MRSA?

A

Delafloxacin

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16
Q

AE of macrolides?

A

QT prolongation + hepatotoxicity

Avoid use with lovastatin/simvastatin w/ clarithromycin or erythromycin

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17
Q

MOA of tetracycline

A

Binds to 30s

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18
Q

Do aminoglycosides cover for MRSA?

A

No

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19
Q

Do aminoglycosides cover for Pseudo?

A

Yes

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20
Q

MOA of clindamycin?

A

Binds to 50s

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21
Q

Clindamycin has gram (positive/negative) coverage

A

Gram positive + anaerobes

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22
Q

Generic of Omnicef?

A

Cedinir

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23
Q

Which Abx cover B. fragilis?

A
  1. Flagyl
  2. BL + BLi
  3. Cefotetan, cefoxitin
  4. Carbapenems
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24
Q

DOC for treating Acineobacter?

A

Merrem

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25
Q

Which Abx decrease seizure threshold?

A

BL + quinolones

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26
Q

Which Abx cover atypicals?

A

Zithromax, tetracyclines, quinolones

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27
Q

When do you stop Abx prior to surgery?

A

1hr for Ancef or cefuroxime

2hrs if quinolone or vanco

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28
Q

DOC for acute otitis media?

A

Amoxicillin or Augmentin ~90mg/kg/day

29
Q

DOC for COPD exacerbation?

30
Q

DOC for outpatient CAP?

A

BL + Macrolide/Doxy oooor respiratory quinolone monotherapy

One of those components are only needed if they have no comorbidities

31
Q

DOC for inpatient CAP?

A

BL + macrolide/respiratory FQ

32
Q

Latent TB tx?

A

R/I once weekly for 12 weeks (daily for rifampin and isoniazid)

Rifampin daily for 4 months

INH daily for 6 or 9 months in pregnant women

33
Q

Active TB tx?

A

RIPE for 2 months

R/I for 4 months

34
Q

RIPE

Which one causes orange-red discoloration?

35
Q

RIPE

Which one causes peripheral neuropathy?

36
Q

RIPE

Which one requires the use of Vit. B6?

A

Isoniazid to decrease peripheral neuropathy

37
Q

RIPE

Which one causes optic neuritis?

A

Ethambutol

38
Q

DOC for infective endocarditis?

A

Vary, but needs 4-6 weeks of treatment

39
Q

DOC for infective endocarditis dental prophylaxis?

A

Amoxicillin 2g

40
Q

DOC for SBP?

A

Ceftriaxone for 5-7 days

41
Q

DOC for SBP ppx?

A

Bactrim or Cipro

42
Q

DOC for impetigo? (yellow crusting around mouth)

A

Cephalexin

43
Q

DOC for folliculitis/furuncles/carbuncles?

A

Systemic? Use Cephalexin

If already used, bactrim or doxy works too

44
Q

DOC for mild cellulitis

A

Cephalexin

45
Q

DOC for purulent abscesses?

A

Bactrim or doxy

46
Q

DOC for severe puruelent SSTI

A

Vanco or Dapto or Zyvox

47
Q

DOC for necrotizing fascitis?

A

Vanco + BL

48
Q

DOC for bacteruria in pregnant patients?

A

Augmentin or oral cephalosporin

49
Q

DOC for traveler’s diarrhea + blood?

50
Q

DOC for syphillis?

A

Bicillin LA 2.4mill

51
Q

DOC for late latent or teriary?

A

Bicillin LA 2.4mill x 3 weeks

52
Q

DOC for neuro or congenital syphillis?

A

Penicillin G aqueous, up to 24 millions units daily x 10-14 days

53
Q

DOC for gonorrhea?

A

Ceftraixone

54
Q

DOC for Chlmaydia?

A

Doxy or Zithromax

55
Q

DOC for rickettsial diseases?

A

Doxycycline generally

56
Q

DOC for traveler’s diarrhea and no blood?

A

Quinolones or Rifaximin

57
Q

Rate of conventional amphotericin B?

A

Dont exceed 1.5mg/kg/day

58
Q

AE of conventional amphotericin B?

A

Mg and Potassium are depleted, nephrotoxicity, infusion related AE

59
Q

When is flucytosine utuilized?

A

In combo w/ amphotericin for cryptococcal meningitis

60
Q

Flucytocin AE?

A

Myelosuppression

61
Q

General AE of all azoles?

A

Increased LFTs, risk of QT prolongation except in isavuconazonium

62
Q

Which azole requires renal adjustments?

A

Fluconazole

63
Q

Which azole causes severe hepatotoxicity?

A

Ketoconazole

64
Q

Which azole causes HF?

A

Itraconazole

65
Q

Which azole causes visual changes and phototoxicity?

A

Voriconazole

66
Q

Which azole has SBECD vehicle in it?

A

Voriconazole and Posaconazole

67
Q

DOC for Aspergillus?

A

Voriconazole

68
Q

Which azole require an acidic environment for absorption?

A

Ketoconazole + itraconazole

69
Q

Acyclovir AE?

A

Nephrotoxicity

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