Endocrine/Pain Flashcards
PTU vs Methimazole, which one is preferred in pregnancy?
PTU = first trimester
Methimazole = second and third trimester
What are used to treat acute gout attacks?
Colchicine + NSAIDs
Dosing of colchicine?
1.2mg PO then 0.6mg in one hour - max of 1.8mg/1hr or 2.4mg/day
Brand of colchicine?
Colcrys
What kind of testing is required prior to using allopurinol?
HLA-B*5801
Which drug for gout needs to be taken with an XOI? And which drug for gout can NOT be taken with an XOI?
Lesinurad - okay to take with XOI
Pegloticase - NOT okay, also dont take with probenecid
Which opioid should not be used in renally impaired pt?
Meperidine
General Tx and prevention options for osteoporosis?
Prevention = bisphosphonates, estrogen based therapy, raloxifene, and Duavee
General Tx and prevention options for osteoporosis?
Prevention = bisphosphonates, estrogen based therapy, raloxifene, and Duavee
TX = bisphosphonates, denosumab, teriparatide, calcitonin
Raloxifene and Duavee (conjugated estrogens/Bazedoxifene) are SERM drugs for osteoporosis, who can get them?
Postmenopausal women only for both
No uterus - raloxifene
Uterus - Duavee
Brand of Raloxifene?
Evista
Which ED drug is affected by high-fat or large meals?
Sildenafil and vardenafil - decreased efficacy
Patients taking alpha-blockers can develop what syndrome?
Intraoperative floppy iris syndrome during cataract surgery
What are the non-selective alpha 1 blockers used for BPH?
Doxazosin + Terazosin
What are the selective alpha - 1A blockers?
Tamsulosin
Brand of Tamsulosin?
Flomax
Brand of Doxazosin?
Cardura
When is finasteride indicated for BPH?
If they have an enlarged prostate
What’s an issue with taking alpha 1 blockers / 5 alpha reductase inhibitors for BPH?
They both take time for maximal efficacy
4-6 weeks for alpha 1 blockers
6 months plus for 5 alpha reductase inhibitors
What are the 5 alpha reductase inhibitors for BPH?
Finasteride
Brand of Finasteride?
Proscar
Typical treatment plan for overactive bladder?
- Anticholinergics (oxybutynin, tolterodine, solifenacin)
- Beta - 3 agonists (mirabegron)
- Botox
Brand of oxybutynin?
Ditropan
Brand of tolerodine?
Detrol
Brand of solifenacin?
Vesicare
C/I of anticholinergics?
Uncontrolled narrow angle glaucoma
Most common cause of hypothyroidism?
Hashimoto
Initial treatment of myxedema coma?
IV levothyroxine
10mg IV morphine = __ mg PO morphine = __ IV/PO hydromorphone = ___ mg oxycodone
10mg IV morphine = 30mg PO morphine = 1.5mg IV / 7.5mg hydrophone = 20mg oxycodone
Unique AE of methadone?
QT prolongation
Initial levothyroxine dose? What is one exception?
1.6mcg/kg/day
Exception: 12.5-25mcg in patients w/ CAD
Most common cause of hyperthyroidism?
Grave’s disease
Treatment of thyroid storm?
PTU + Lugol’s solution / SSKI + beta blocker + steroid + cooling/APAP
