Endocrine/Pain

Question 1

PTU vs Methimazole, which one is preferred in pregnancy?

Answer 1

PTU = first trimester

Methimazole = second and third trimester

Question 2

What are used to treat acute gout attacks?

Answer 2

Colchicine + NSAIDs

Question 3

Dosing of colchicine?

Answer 3

1.2mg PO then 0.6mg in one hour - max of 1.8mg/1hr or 2.4mg/day

Question 4

Brand of colchicine?

Answer 4

Colcrys

Question 5

What kind of testing is required prior to using allopurinol?

Answer 5

HLA-B*5801

Question 6

Which drug for gout needs to be taken with an XOI? And which drug for gout can NOT be taken with an XOI?

Answer 6

Lesinurad - okay to take with XOI

Pegloticase - NOT okay, also dont take with probenecid

Question 7

Which opioid should not be used in renally impaired pt?

Answer 7

Meperidine

Question 8

General Tx and prevention options for osteoporosis?

Answer 8

Prevention = bisphosphonates, estrogen based therapy, raloxifene, and Duavee

Question 8

General Tx and prevention options for osteoporosis?

Answer 8

Prevention = bisphosphonates, estrogen based therapy, raloxifene, and Duavee

TX = bisphosphonates, denosumab, teriparatide, calcitonin

Question 9

Raloxifene and Duavee (conjugated estrogens/Bazedoxifene) are SERM drugs for osteoporosis, who can get them?

Answer 9

Postmenopausal women only for both

No uterus - raloxifene

Uterus - Duavee

Question 10

Brand of Raloxifene?

Answer 10

Evista

Question 11

Which ED drug is affected by high-fat or large meals?

Answer 11

Sildenafil and vardenafil - decreased efficacy

Question 12

Patients taking alpha-blockers can develop what syndrome?

Answer 12

Intraoperative floppy iris syndrome during cataract surgery

Question 13

What are the non-selective alpha 1 blockers used for BPH?

Answer 13

Doxazosin + Terazosin

Question 14

What are the selective alpha - 1A blockers?

Answer 14

Tamsulosin

Question 15

Brand of Tamsulosin?

Answer 15

Flomax

Question 16

Brand of Doxazosin?

Answer 16

Cardura

Question 17

When is finasteride indicated for BPH?

Answer 17

If they have an enlarged prostate

Question 18

What’s an issue with taking alpha 1 blockers / 5 alpha reductase inhibitors for BPH?

Answer 18

They both take time for maximal efficacy

4-6 weeks for alpha 1 blockers

6 months plus for 5 alpha reductase inhibitors

Question 19

What are the 5 alpha reductase inhibitors for BPH?

Answer 19

Finasteride

Question 20

Brand of Finasteride?

Answer 20

Proscar

Question 21

Typical treatment plan for overactive bladder?

Answer 21

1. Anticholinergics (oxybutynin, tolterodine, solifenacin)
2. Beta - 3 agonists (mirabegron)
3. Botox

Question 22

Brand of oxybutynin?

Answer 22

Ditropan

Question 23

Brand of tolerodine?

Answer 23

Detrol

Question 24

Brand of solifenacin?

Answer 24

Vesicare

Question 25

C/I of anticholinergics?

Answer 25

Uncontrolled narrow angle glaucoma

Question 26

Most common cause of hypothyroidism?

Answer 26

Hashimoto

Question 27

Initial treatment of myxedema coma?

Answer 27

IV levothyroxine

Question 28

10mg IV morphine = __ mg PO morphine = __ IV/PO hydromorphone = ___ mg oxycodone

Answer 28

10mg IV morphine = 30mg PO morphine = 1.5mg IV / 7.5mg hydrophone = 20mg oxycodone

Question 29

Unique AE of methadone?

Answer 29

QT prolongation

Question 30

Initial levothyroxine dose? What is one exception?

Answer 30

1.6mcg/kg/day

Exception: 12.5-25mcg in patients w/ CAD

Question 31

Most common cause of hyperthyroidism?

Answer 31

Grave’s disease

Question 32

Treatment of thyroid storm?

Answer 32

PTU + Lugol’s solution / SSKI + beta blocker + steroid + cooling/APAP