IBD Flashcards
What are the key features of ulcerative colitis?
continuous superficial inflammation
colon only
risk of cancer
How does ulcerative colitis present?
diarrhea (bloody w/mucus) abd pain/tenderness loss of appetite & weight fever fatigue urgeny for bowel movement growth/devo failure in kids
What is seen with endoscopy of UC?
erythema loss of vascular pattern granularity of mucosa friability edema pseudopolyps erosions ulcers spontaneous bleeding cecal patch backwash ileitis
What is fulminant colitis?
severe UC w:
-fever, elevated WBC and unstble vitals
(need to rule out C diff)
-risk of perforation
What are the key features of chron’s disease?
patchy full-wall-thickness inflamation cobblestone involvement patchy inflammation fistulae strictures
What is the most common location for chron’s disease to affect?
SI/proximal colon
How does chron’s disease present in kids?
abdominal pain diarrhea weight loss anorexia vomiting rectal bleeding stunted growth fevers
How does chron’s disease present in adults?
similar to kids except fewer growth issues
What are the most common endoscopic findings for chron’s?
aphthous ulcers
cobblestoning
discontinuous (skip) lesions
linear “rake like”/serpigionous ulcers
What are findings that favor chron’s over UC?
rectal sparing
normal vascularture next to affected tissue
isolated involvement of the terminal ileum (backwash ileitis only seen in pancolitis)
fistula/strictures
granulomas on biopsy
What are common extra intestinal manifestations of IBD?
acute arthropaty
erythema nodosum
choledocholithiasis
What are skin complications in chron’s disease?
erythema nodosum
pyoderma gangrenosum
What are common opthamic findings in UC?
episcleritis
uveitis
What gene is implicated in severe chron’s?
NOD2 mutations
What is the predominant non-genetic factor contributing in IBD?
colonizing bacteria
