Heme Catabolism & Bile Salts Flashcards
1
Q
Big Picture: what happens in the macrophage?
A
heme ring opening –> biliverdin –>bilirubin
2
Q
Big picture: what happens in the blood?
A
albumin carries bilirubin from macrophage to liver
3
Q
Big picture: what happens in liver hepatocytes?
A
bilirubin is conjugated with glucuronic acid, excreted
4
Q
Big picture: what happens in the GI tract?
A
conjucgated bilirubin is converted by baccteria, removal of glucuronic acid (ie/deconjucated) conversion to urobilinogen
5
Q
Big picture: what happens in the kidney?
A
conversion of urobilinogen, products to urobilin, excreted in urine
6
Q
Where is bilirubin normally excreted?
A
the bile
7
Q
What do inherited disorders of bilirubin metabolism lead to?
A
hyperbilirubinemia
