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Endocrine II > Hypothalamic and pituitary drugs > Flashcards

Hypothalamic and pituitary drugs Flashcards

1
Q

Goserelin
Leuprolide
Nafarelin
Histrelin
are example of what drug class, MOA, indications, s/e?

A

GnRH agonists Transient agonist effects are followed by the suppression of the hypothalamic-pituitary-gonadal axis.
Cancer (continuous administration)
Breast cancer
Prostate cancer
Infertility (pulsatile administration)
Endometriosis
Precocious puberty
S/E: hypogonadism; osterporosis

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2
Q

GnRH antagonists

A

Degarelix

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3
Q

Block GnRH receptors on pituitary to decrease FSH and LH secretion

A

Degarelix

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4
Q

Elevated liver enzymes

A

Degarelix

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5
Q

Infertility (pulsatile administration

A

Leuprolide

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6
Q

Decreased bone mineral density

A

GnRH agonists

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7
Q

Somatostatin analogs example

A

Octreotide
Lanreotide

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8
Q

MOA of somatostatin analogs

A

Inhibit GH secretion

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9
Q

Octreotide is use for

A

Acromegaly, VIPoma

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10
Q

Side effect of somatostatin analogs

A

Cholelithiassis

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11
Q

GHRH analogs example

A

Tesamorelin

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12
Q

GHRH analogs MOA

A

Stimulate GH receptors

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13
Q

GHRH analogs use:

A

GH deficiency
Turner
Short stature

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14
Q

Side effect of GHRH analogs

A

Increase insulin resistance
Intracranial HTN
Gynecomastia

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15
Q

GH receptor antagonists example

A

Pegvisomant

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16
Q

MOA GH receptor antagonist

A

Block GH receptor

17
Q

Acromegaly

A

Pegvisomant
GH receptor antagonists

18
Q

Pegvisomant s/e

A

Hepatotoxicity

19
Q

Bromocriptine
Cabergoline

A

Dopamine agonists

20
Q

MOA for Dopamine agonists

A

Stimulate dopamine receptors

21
Q

Prolactinoma

A

Dopamine agonists

22
Q

Dopamine agonists s/e

A

Orthostatic hypotension
Confusion, hallucination

23
Q

Hypernatremia

A

ADH antagonists

24
Q

ADH antagonists ex

A

Conivaptan
Tolvaptan
Demeclocycline (a tetracycline)

25
Q

MOA Conivaptan

A

selective V2 receptor antagonis

26
Q

Block V2 receptors and decrease water reabsorption in the renal collecting duct

A

Conivaptan

27
Q

ADH analogs ex

A

Desmopressin
Terlipressin

28
Q

ADH analogs s/e

A

Hyponatremia

29
Q

MOA ADH analogs

A

Act on the V1 and V2 receptors
Release vWF stored in the endothelium

30
Q

ADH analogs use

A

Central DI

31
Q

Mediates calcium influx → uterine contraction

A

Oxytocin

32
Q

Oxytocin usae

A

Induction of labor
Augmentation of labor
Postpartum hemorrhage

33
Q

S/E oxytocin

A

Hyponatremia
Tachysystole
Hypotension

Endocrine II (16 decks)

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