Hypoproliferative Anemia Study Guide Flashcards
What are the two main causes of anemia of chronic disease?
Decreased release of erythropoietin and increased expression in hepcidin
What will prussian blue stain show in anemia of chronic disease?
Increased iron sequestration in macrophages and bone marrow
What happens to ferritin levels in anemia of chronic disease?
What happens to serum iron levels?
They increase to bind loose iron
They go down
What causes anemia of renal failure?
What are the RBCs like?
decreased erythropoietin
normocytic, normochromic
What causes megaloblastic anemia?
What are the RBCs like?
Impaired DNA synthesis
Macrocytic; they are grow and accumulate proteins, but are unable to enter into mitosis
What are two deficiencies that can cause megaloblastic anemia?
folate deficiency
B12 deficiency
What is myelophthisic anemia?
What other findings are seen?
Anemia caused by bone metastasis of a carcinoma
Leukoerythroblastic reaction and tear drop cells
What is pure red cell aplasia?
What is believed to cause it?
selective inhibition of erythropoiesis
autoimmune reactions
