Diseases - Cytogenetic abnormalities, Markers, and Other unique features

Question 1

JAK2 kinase mutation

Answer 1

PV (100%)

MF (50%)

ET (50%)

Question 2

t(9,22)

Answer 2

CML

B-ALL

Question 3

-5q, -7q, +8

Answer 3

MDS

Question 4

t(15;17)

Answer 4

APL (AML)

Question 5

t(15;17), t(8;21), del(16)

11q23

Answer 5

AML: good prognosis

AML: bad prognosis

Question 6

Langherhans cell histiocytosis

Answer 6

CD1, langherin, BRAF

Question 7

markedly increased ferritin

Answer 7

HLH

Question 8

Reactive T-lymphocytes, polylconal

Answer 8

Inflammatory mononucleosis

Question 9

TdT

Answer 9

ALL (T and B)

Question 10

TdT with t(13;21) or hyperdiploidy

TdT with t(9;22), hypodipoloidy, or 11q23

Answer 10

ALL - good prognosis

ALL - bad prognosis

Question 11

CD5/19/23

Answer 11

CLL/SLL

Question 12

CLL/SLL ctyogenetics, name:

Good prognosis

Intermediate prognosis

Bad prognosis

Answer 12

13q, IGHV(+)

+12

11q, 17p, IGHV(-)

Question 13

TRAP, CD11a, CD22

Answer 13

Hairy cell leukemia

Question 14

CD4, CD25, HTLV-1

Answer 14

ATLL

Question 15

CD4, cerebriform nuclei

Answer 15

MF/SS

Question 16

CD8, eosinophilic granules

Answer 16

LGLL

Question 17

Mnemonic for end organ damage in MM

Answer 17

CRAB

hyperCalcemia

Renal damage

Anemia

Bone disease

Question 18

Highly localized Plasma cell neoplasm, may be associated with MM

Answer 18

Plasmacytoma

Question 19

IgM

Answer 19

LPL

Question 20

Like MM, but with no end-organ damage

Answer 20

MGUS

Question 21

CD10/19/20

Answer 21

Follicular lymphoma

Burkitt lymphoma

Question 22

CD19/20

Answer 22

MALToma (extranodal)

DLBCL

Question 23

T-helper cells, usually observed in adults, aggressive

Answer 23

Peripheral TCL

Question 24

CTLs, ALK rearrangements, seen primarily in children, aggressive

Answer 24

Anaplastic LCL

Question 25

NK, associated with EBV and South America or Asia, usually sinonasal, very aggressive/destructive

Answer 25

Extranodal NK/T

Question 26

CD20/45, popcorn cells

Answer 26

NLPHL

Question 27

CD15/30

Answer 27

Classic HL

Question 28

Reed-Sternberg cells

Answer 28

Classic HL

Question 29

"Soccer Ball" nucleus with "Ginger Snap" chromatin

Answer 29

CLL/SLL

Question 30

"Flower cells"

Answer 30

ATLL

Question 31

CD8, eosinophilic granules, associated with autoimmune disease (RA, etc)

Answer 31

LGLL

Question 32

t(11;18)

Answer 32

Extranodal marginal zone lymphoma (MALToma)