Hypersensitivity ☺️ Flashcards
1
Q
Describe the T1 response
- pathophysiology
- examples
- presentation
- testing
A
IMMEDIATE HYPERSENSITIVITY
-allergy, atopy, anaphylaxis
Antigen reacts with IgE bound to mast cell
- histamine - vascular permeability, BC, VD => wheal and flare
- tryptase - tissue remodeeling, mucosecretion
- PGI, LT, cytokines
Resp -BC, wheeze -rhinitis, sneeze Eye -conjunctivitis Skin -AD GI -food allergy
Skin prick
Total IgE, specific IgE (RAST)
Transient increase of tryptase
2
Q
Describe the T2 response
- pathophysiology
- examples
A
AB-AG on cells/tissue => complement cascade
Opsonisation => phagocytosis
-AI hemolytic anemia
-Haemolysis in transfusion
Complement, Fc inflammation
- Glomerulonephritis
- ANCA vasculitis
AB inappropriately changes processes
- Myasthenia gravis
- Graves
3
Q
Describe the T3 response
- pathophysiology
- examples
A
Accumulation of AB-AG complexes => immune response
- SLE
- post strep GN
- serum sickness
4
Q
Describe the T4 response
- pathophysiology
- examples
A
delayed cell mediated response via
- cytokines => inflammation
- T cell mediated damage
Asthma, IBD
T1D
Myocarditis