Hydroxylation Flashcards
1
Q
purpose?
A
syn-addition of 2 OHs to make a diol
2
Q
2 types of reagent
A
OsO4 (osmium tetraoxide)
KMnO4 (potassium permanganate)
3
Q
OsO4
A
volatile, toxic, expensive, good catalyst (good yield)
4
Q
KMnO4
A
safer, cheaper, worse yield
5
Q
OsO4 rxn conditions
A
2 steps
OsO4, THF, 25ºC
H2O2, NaOH (dilute) / H2S
6
Q
KMnO4 rxn conditions
A
1 step
KMnO4, H2O, NaOH, 0ºC (COLD)
