HTN Meds

Question 1

nitrate mechanism

Answer 1

promote venous relaxation. dephosphoralates (myosin needs a P to contract)

Question 2

CA2 blocker mech

Answer 2

block MLCK activation, myosin can’t get phosphorylated. also stop calcium from reaching SA node (HR)

Question 3

Beta blocker MOA

Answer 3

block G protein activation, Ca channels can’t open

Question 4

Alpha 2 agonist MOA

Answer 4

decrease tone, dilate artery

Question 5

alpha 1 antagonist MOA

Answer 5

block post synapse, no NE effect

Question 6

BP=

Answer 6

Co*svr

Question 7

Co breaks down into

Answer 7

SV and HR

Question 8

SV breaks Dorn into

Answer 8

preload and contractibility

Question 9

complications of diuretics

Answer 9

sexual dysfunction in men, new onset DM, worsening lipids, hypokalemia, gout

Question 10

complications of renin angiotensin blokage

Answer 10

cough, hypotension, hyperkalemia, deterioration in kidney function, angioedema, NO FOR PREGO

Question 11

first line drug

Answer 11

thiazide

Question 12

hypertensive nephrosclerosis

Answer 12

symmetrical decreased kidney size, sub capsular fine granularity, think kidney cortex, normal calyces

Question 13

nephropathy

Answer 13

end organ damage… proteinuria disease highest risk of CVa

Question 14

african americans

Answer 14

diuretics and calcium increased effect, also beta blocker and Acei, also more sensitive to Na restriction