Nephrotic Syndrome

Question 1

nephrotic syndrome symptoms

Answer 1

proteinuria, hypoalbuminemia, edema, hyperlipidemia

Question 2

cultures/kidney function in nephrotic syndrome

Answer 2

negative, negative sed, normal GFR/CREAT, normal BP

Question 3

primary diseases

Answer 3

Minimal change disease, focal segmental glomerulosclerosis, membranous glomerulopathy

Question 4

Minimal change disease

Answer 4

CHILDREN, immune mediated, immune disfunction, hereditary. Treat: steroids

Question 5

FSCS

Answer 5

Obesity is a risk factor> leads to recurrent ESRD,

Question 6

Membranous Glomerulopathy

Answer 6

Adults, autoimmune, cancer, infection. poor steroid response

Question 7

Minimal change disease associated

Answer 7

leukemia, lymphoma, NSADS

Question 8

Minimal change disease biopsy

Answer 8

normal LM, EM podocyte death

Question 9

steroids work for which?

Answer 9

MCD

Question 10

FSCS biopsy

Answer 10

focal glomerular scarring, EM: diffuse podocytes

Question 11

which primary has subendotheial ab?

Answer 11

membranous glomer.

Question 12

membranous imagine

Answer 12

lm: think/pink, open caps, granular IgG staining along cap wall.

Question 13

secondary causes

Answer 13

diabetes, amyloidosis, MSAIDS, lithium, tumor, infection

Question 14

Diabetes

Answer 14

clin: mibralbumerima. hypergllycemia>protein glycosylation> increase collagen in GBm

Question 15

diabetes nephrotic biopsy

Answer 15

sclerosed, nodular, compressed cap lumen, thick membrane matrix

Question 16

amyloidosis biopsy

Answer 16

fibrosis, CONGO RED, GM fibrosis

Question 17

general treatment

Answer 17

immunosuppression (from loss of immunoglobulin in the urine), hypercoagulability (from loss of coagulation factors protein C, protein S, and anti-thrombin III), and increased vascular risk must be addressed.

Question 18

how is phosphorus cleared

Answer 18

glom filtration!!