Hox Genes & Segmentation

Question 1

What are rhombomeres

Answer 1

seven segments of tissue developed in the hindbrain of vertebrates

Question 2

Describe the segmentation of drosophila

Answer 2

thorax; - T1-T3 and abdomen; - A1-A8

Question 3

What does recessive mutations in the ultrabithorax gene cause

Answer 3

transformation of the third thoracic segment into the second thoracic

Question 4

Describe a homeotic transformation

Answer 4

one structure is replaced by another

Question 5

What is the function of Ubx

Answer 5

Ubx regulates the developmental programme of T3

Question 6

What dos Ubx act as

Answer 6

selector genes to specify identity of halteres

Question 7

Describe autonomous function

Answer 7

mutation affects cells in which it is present

Question 8

What can cause an autonomous mutation

Answer 8

transcription factor and receptors

Question 9

Describe non-autonomous function

Answer 9

mutation affects the cells around it

Question 10

What can cause a non-autonomous mutation

Answer 10

signalling molecule

Question 11

What do the imaginal discs give rise to in the fly

Answer 11

structures of the adult fly

Question 12

What pathway does Ubx direct cells down

Answer 12

metathoracic pathway of development

Question 13

What transformations does abdominal B cause

Answer 13

transformation of abdominal segments into a different identity

Question 14

What genes make up the bithorax complex?

Answer 14

Ubx, AbdB and abdA

Question 15

What is the homeobox

Answer 15

highly conserved motif

Question 16

What does the homeobox code for

Answer 16

homeodomain

Question 17

What is the homeodomain

Answer 17

sequence specific DNA binding motif

Question 18

What does the arrangement of genes in the bithorax complex reflect

Answer 18

order of function along AP axis

Question 19

Describe the expression of the bithorax complex

Answer 19

spatially restricted along AP part of animal

Question 20

TRUE or FALSE - Bithorax complex is required for segmentation process

Answer 20

FALSE

Question 21

What is the function of the Bithorax complex?

Answer 21

specify segmentation and body plan

Question 22

What is the antennapedia complex required for

Answer 22

makes anterior type structures

Question 23

What development does the antennapedia complex control

Answer 23

head and thoracic segments

Question 24

What segment does the antennapedia complex control

Answer 24

T2

Question 25

what do dominant mutations of the antennapedia complex cause

Answer 25

legs grow where the antenna should be

Question 26

What do Hox genes code for

Answer 26

DNA binding proteins that regulate transcription

Question 27

Describe the conservation of hox genes

Answer 27

highly conserved throughout evolution