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BMS109 Develpomental > Making a Neuron > Flashcards

Making a Neuron Flashcards

1
Q

What specification is needed to make a neuron

A

specification of neurectoderm & neuroblasts

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2
Q

What does neurectoderm become in drosophila CNS

A

neurons & epidermis

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3
Q

Where does the nervous system form in drosophila

A

ventral side

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4
Q

What is a ganglion

A

collection of neurons

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5
Q

What are proneural clusters

A

groups of cells in neurectoderm

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6
Q

What is the position of proneural clusters determined by

A

AP & DV axis

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7
Q

What is the primary fate of proneural clusters

A

neuroblast

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8
Q

What is the secondary fate of proneural clusters

A

epidermis

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9
Q

How do neurectoderm form neuroblasts

A

lateral inhibition

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10
Q

What mediates lateral inhibition

A

delta-notch signalling

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11
Q

How does signalling via delta effect notch

A

cleavage of notch intracellular domain

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12
Q

Example of an equivalence group

A

proneural cluster

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13
Q

Why is a proneural cluster an equivalence group

A

because all cells have the same potential

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14
Q

Describe the phenotype caused by over production of neuroblasts

A

lethal

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15
Q

What does notch code for

A

receptor protein

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16
Q

What does delta code for

A

tethered transmembrane protein

17
Q

What type of signalling do delta-notch exhibit

A

juxtacrine

18
Q

What is the effect of cleavage events on delta notch signalling

A

notch intracellular domain cleaves & becomes part of transcription factor

19
Q

What feedback loop is exhibited by delta-notch

A

positive feedback loop

20
Q

What is the advantage of using positive feedback for delta-notch signalling

A

amplifies difference

21
Q

TRUE or FALSE - Delta can diffuse

A

FALSE

22
Q

Describe the division of neuroblasts

A

asymmetric

23
Q

What type of cell are neuroblasts

A

stem cells

24
Q

What innervates mechanosensory bristles

A

sensory neurons

25
Q

What are the cell types in sensory bristles

A

sensory neuron, hair cell, socket cell and sheath cell

26
Q

What inhibits notch activity

A

numb

27
Q

What does over expression of notch cause in sensory organ precursors

A

four socket cells

28
Q

What does loss of notch function cause in sensory organ precursors

A

four neurons

29
Q

what is the function of the growth cone

A

helps axon find targets

30
Q

What is the effect of repulsive cues on the axon

A

turn axon away

31
Q

What act as long range cues

A

diffusible molecules

32
Q

What act as short range cues

A

cell surface molecules E.G. cadherins

33
Q

What does the growth cone use to explore the environment

A

filopodia

34
Q

How are neural connections refined

A

pruning and cell death

BMS109 Develpomental (13 decks)

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