Making a Neuron Flashcards
What specification is needed to make a neuron
specification of neurectoderm & neuroblasts
What does neurectoderm become in drosophila CNS
neurons & epidermis
Where does the nervous system form in drosophila
ventral side
What is a ganglion
collection of neurons
What are proneural clusters
groups of cells in neurectoderm
What is the position of proneural clusters determined by
AP & DV axis
What is the primary fate of proneural clusters
neuroblast
What is the secondary fate of proneural clusters
epidermis
How do neurectoderm form neuroblasts
lateral inhibition
What mediates lateral inhibition
delta-notch signalling
How does signalling via delta effect notch
cleavage of notch intracellular domain
Example of an equivalence group
proneural cluster
Why is a proneural cluster an equivalence group
because all cells have the same potential
Describe the phenotype caused by over production of neuroblasts
lethal
What does notch code for
receptor protein
What does delta code for
tethered transmembrane protein
What type of signalling do delta-notch exhibit
juxtacrine
What is the effect of cleavage events on delta notch signalling
notch intracellular domain cleaves & becomes part of transcription factor
What feedback loop is exhibited by delta-notch
positive feedback loop
What is the advantage of using positive feedback for delta-notch signalling
amplifies difference
TRUE or FALSE - Delta can diffuse
FALSE
Describe the division of neuroblasts
asymmetric
What type of cell are neuroblasts
stem cells
What innervates mechanosensory bristles
sensory neurons
What are the cell types in sensory bristles
sensory neuron, hair cell, socket cell and sheath cell
What inhibits notch activity
numb
What does over expression of notch cause in sensory organ precursors
four socket cells
What does loss of notch function cause in sensory organ precursors
four neurons
what is the function of the growth cone
helps axon find targets
What is the effect of repulsive cues on the axon
turn axon away
What act as long range cues
diffusible molecules
What act as short range cues
cell surface molecules E.G. cadherins
What does the growth cone use to explore the environment
filopodia
How are neural connections refined
pruning and cell death
