How do we do research

Question 1

4 research considerations

Answer 1

-is it new +exciting
-is it important to study and could this lead to something that is useful
-having resources: money, facilities and skills
-is it practical/feasible to study

Question 2

2 ways gene expression be seen?

Answer 2

by RT-PCR, transcriptomics(RNA-seq, microarrays

Question 3

what can gene encoding protein be done by?

Answer 3

genome editing

Question 4

4 ways questions can be asked about a disease before you do the research?

Answer 4

-what are potential causes and treatment: can be done through systematic reviews
-who it targets
-prevalence
-lifestyle risk or protective factors

Question 5

3 studies can be to investigate a disease before doing research?

Answer 5

cross-sectional/cohort studies, ecological study

Question 6

Randomised control trials

Answer 6

doing these to different populations would be unethical

Question 7

how to screen for an inhibitor ?

Answer 7

needs in vitro biochemical assay

Question 8

yes or no, does the inhibitor take long to develop the drug?

Answer 8

yes

Question 9

in human trials, what happens in the 0 phase?

Answer 9

will be tested in mammals or primates to then test on humans -test toxicity

Question 10

in human trials what happens in phase 1?

Answer 10

Laboratory study is done the volunteers come in , to test for side effects , after it is approved safe on the volunteer.

Question 11

in human trials , what happens in phase 2?

Answer 11

Then it will be tested on the people with the disease

Question 12

in human trials, what happens in phase 3?

Answer 12

trial runs for many years-effectiveness and treating disease and can be cross countries to test on different populations.

Question 13

in human trial, what happens in phase 4?

Answer 13

larger scale safety and effectiveness

Question 14

in human trials, what happens in phase 5?

Answer 14

long term safety -it is ongoing

Question 15

one side effect of drugs?

Answer 15

nausea