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Toxicology > Household Toxins > Flashcards

Household Toxins Flashcards

1
Q

Ethylene glycol is oxidized to

A

Oxalic acid - binds serum Ca

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2
Q

MOA for Ethylene glycol

A

GI irritation
Osmotic diuresis
CNS depression

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3
Q

MOA for Ethylene glycol metabolites

A

Met acidosis

Acute renal failure (crystals calcium oxalate mono)

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4
Q

Ethylene glycol signs - Early

A

30 min - 12 hr

Vomit, CNS depression, Incoordination, hypothermia, tremors, tachycardia/pnea, PU/PD

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5
Q

Ethylene glycol signs - Late

A

24-72 h

Oliguric renal failure

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6
Q

Ethylene glycol lesions

A

Hemorrhagic enteritis
Pulmonary edema
Pale, swollen kidney w/ gray or yellow streaks

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7
Q

Ethylene glycol produces anion gaps of

A

More than 40-50 mEq/L

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8
Q

Ethylene glycol chemistry results

A

Hypocalcemia
Hyperglycemia
BUN, Cr, Hyper P/K

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9
Q

Ethylene glycol treatment

A

Inhibitors of alcohol dehydrogenase
Fomepizole
Ethanol 20%

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10
Q

Which species is more sensitive to propylene glycol

A

Cats

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11
Q

propylene glycol is metabolized to ____ which _____ and may cause _____

A

D-Lactic acid - accumulates and may cause lactic acidosis

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12
Q

MOA of propylene glycol

A

Osmotic diuresis
CNS depression
Heinz body

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13
Q

propylene glycol signs

A

Ataxia and CNS depression
Heinz body
Muscle twitching

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14
Q

propylene glycol lab finding

A

Met acidosis
Hyperosmol
Anion gap

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Toxicology (8 decks)

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