Hormones Flashcards
Name the function and location of ACTH (Adrenocorticotropic Hormone)
function: stimulates the adrenal cortex to release stress hormone called “glucocorticoids”
location: anterior pituitary
ACTH is – soluble
peptide/water-soluble
stimulates the adrenal cortex to release stress hormone called “glucocorticoids”
ACTH (adrenalcorticotropic hormone)
Where is ACTH located?
anterior pituitary
surge causes ovulation; stimulates the
secretion of the sex hormones estrogen and testosterone
LH (Luteinizing hormone)
LH is – soluble
peptide/water soluble
Where is LH located?
anterior
pituitary
stimulates growth of the follicle during menstrual
cycle and production of sperm
FSH (Follicle stimulating hormone)
Where is FSH located?
anterior
pituitary
FSH is – soluble
peptide/water soluble
stimulates release of T3/T4 from the thyroid
TSH (thyroid stimulating hormone)
TSH is – soluble
peptide/water soluble
TSH is located in the
anterior
pituitary
stimulates growth throughout the body
hGH (Human growth hormone)
hGC is – soluble
peptide/water soluble
stimulates milk production in the breasts
Prolactin
Prolactin is located in the
anterior
pituitary
Prolactin is – soluble
peptide/water soluble
causes the collecting duct of the kidney to become highly permeable to water, concentrating the urine
ADH (Antidiuretichormone)
ADH is – soluble
peptide/water soluble
ADH location
posterior pituitary
stimulates contractions during childbirth and milk
secretion during nursing
Oxytocin
Oxytocin is – soluble
peptide/water soluble
Oxytocin location
posterior pituitary
increases blood calcium by stimulating proliferation
of osteoclasts, uptake of Ca2+ in the gut, and
reabsorption of Ca2+ in the kidney
parathyroid hormone
parathyroid hormone location
parathyroid
parathyroid hormone is – soluble
peptide/water soluble
stimulates uptake and storage of glucose from the
blood
insulin
location is insulin
pancreas
insulin is – soluble
peptide/water soluble
stimulates gluconeogenesis and release of glucose
into the blood
glucagon
glucagon location
pancreas
glucagon is – soluble
peptide/water soluble
decreases blood calcium by inhibiting osteoclasts
Calcitonin
Calcitonin location
thyroid
Calcitonin is – soluble
peptide/water soluble
Human Growth Hormone (HGH) location
anterior pituitary
prevents degeneration of the corpus luteum,
maintaining pregnancy
hCG (Human chorionic gonadotropin)
hCG is – soluble
peptide/water soluble
hCG location
egg/placenta
increases Na+ reabsorption and K+ secretion at the
distal convoluted tubule and the collecting duct; net
increase in salts in the plasma, increasing osmotic
potential and subsequently blood pressure
Aldosterone
Aldosterone is – soluble
steroid/lipid soluble
Aldosterone location
adrenal cortex
a stress hormone; increases gluconeogenesis in the liver and thus blood glucose levels; stimulates fat
breakdown
Cortisol
Cortisol location
adrenal cortex
Cortisol is – soluble
steroid/lipid soluble
stimulates development of secondary sex
characteristics and closing of epiphyseal plates
Testosterone
Testosterone location
gonads
(testes)
Testosterone is – soluble
steroid/lipid soluble
stimulates female sex organs; causes LH surge in
menstruation
Estrogen
Estrogen location
gonads
(ovaries)
Estrogen is – soluble
steroid/lipid soluble
stimulates growth and maintenance of uterus during
pregnancy
Progesterone
Progesterone location
gonads
(ovaries)
Progesterone is – soluble
steroid/lipid soluble
increases basal metabolic rate, effecting metabolism
T3 & T4
T3 & T4 are – soluble
tyrosine
derivative/lipid
-soluble
T3 & T4 location
thyroid
cause responses almost identical to a sympathetic
nervous system response (fight or flight)
Epinephrine &
Norepinephrine
Epinephrine &
Norepinephrine location
adrenal
medulla
Epinephrine &
Norepinephrine are – soluble
tyrosine
derivative/
water-soluble
Hormones located in the anterior pituitary gland
ACTH, LH, FSH, TSH, hGH, prolactin
Hormones located in the posterior pituitary
ADH and oxytocin
Hormones located in the parathyroid gland
parathyroid hormone
Hormones located in the pancreas
insulin and glucagon
Hormones location in the thyroid
T3 & T4, and calcitonin
Hormones located in the eggs/placenta
hCG
Hormones located in the adrenal cortex
Aldosterone and cortisol
Hormones located in the gonads
(testes)
testosterone, progesterone, and estrogen
Hormones located in the adrenal
medulla
Epinephrine &
Norepinephrine
Hormones that are peptide/water soluble
Anterior pituitary
ACTH
LH
FSH
TSH
hGH
Prolactin
**Posterior pituitary **
ADH
Oxytocin
Parathyroid
Parathyroid
Pancreas
Insulin
Glucagon
**Thyroid **
Calcitonin
Egg/placenta
hCG
Hormones that are steroid/lipid soluble
Adrenal Cortex
Aldosterone, Cortisol
Gonads/testes
Testosterone, Estrogen, and Progesterone
Hormones that are tyrosine
derivative/lipid
-soluble
T3 & T4
Epinephrine and Norepinephrine
Releases the corticoids: aldosterone (mineralocorticoids) and cortisol (glucocorticoids).
Also releases androgens which are converted to testosterone and estrogen in gonads.
Adrenal cortex
Part of the renin-angiotensin II-aldosterone system in the kidneys.
↑ blood pressure by ↑ water absorption from kidneys.
Key role in electrolyte balance: ↑ Na+ absorption and ↓ K+ absorption.
Aldosterone
Key regulator of the stress response.
↑ gluconeogenesis (↑ blood glucose)
↓ immune system activity
Cortisol
After a meal, adipocyte cells release this hormone to trigger appetite suppression.
Leptin
Fasting state triggers Gastric cells to release this hormone triggering hunger.
Ghrelin
The kidneys produce this hormone which triggers production of red blood cells.
(EPO) Erythropoietin
Made in the pineal gland.
Controls circadian rhythm and sleep-wake cycle.
Melatonin
Made in the pancreas. Regulates the endocrine system and GI tract.
Inhibits the release of growth hormone (GH) from the anterior pituitary.
Somatostatin
Releases catecholamines: epinephrine and norepinephrine.
Catecholamines activate the fight-or-flight response.
Adrenal Medulla
A class of hormones that is hydrophilic and derived from the molecule tyrosine.
Catecholamines
Important distinction: the adrenal cortex makes steroid hormones while the medulla makes catecholamines.
Induce the fight-or-flight response of the sympathetic nervous system that aims to maximize blood flow, blood glucose, and oxygen delivery.
↑ blood pressure
↑ heart rate
↓ glycogenesis
↑ airway flow
Epinephrine and norepinephrine
Hormones produced by the anterior pituitary:
FSH, LH, ACTH, TSH, prolactin, endorphins, GH.
Mnemonic: FLAT PEG.
In females: stimulates ovarian follicle growth.
In males: stimulates spermatogenesis.
FSH
In females: stimulates ovulation.
In males: stimulates production of testosterone.
High estrogen leads to ↑ LH and ↓FSH.
LH
Stimulates production of cortisol as part of the hypothalamic-pituitary-adrenal axis:
Adrenocorticotropic hormone (ACTH)
Corticotropin-releasing hormone (CRH) (hypothalamus) → ACTH (anterior pituitary) → cortisol (adrenal cortex)
Stimulates the thyroid to produce triiodothyronine (T3) and thyroxine (T4), which help regulate basal metabolic rate.
TSH
Stimulates production of breast milk and will shut down sexual desire after orgasm. Release is inhibited by dopamine.
Prolactin
Block the sensation of pain while inducing feelings of euphoria and pleasure.
Endorphins
Stimulates bone growth during childhood/adolescence.
Stimulated by GHRH from the hypothalamus and inhibited by somatostatin.
Growth Hormone (GH)
Thyroid hormones regulate –.
Thyroid and parathyroid together regulate – in the body.
metabolism, calcium metabolism
Control the basal metabolic rate.
Thyroid hormones (T3 and T4)
Note: thyroid hormones are their own class of hormones (distinct from catecholamines, peptide, or steroid hormones). They are hydrophobic
Made by parafollicular C cells in the thyroid.
Decreases calcium in the blood.
Mechanism: ↓ bone resorption and ↑ renal excretion.
Calcitonin
↑ calcium and ↓ phosphorus in the blood.
Mechanism: ↑ osteoclast activity for bone breakdown.
Parathyroid hormone
Hormones of the posterior pituitary:
Oxytocin and Antidiurectic hormone (ADH).
Important difference from the anterior pituitary: these hormones are made in the hypothalamus and released from the posterior pituitary.
Stimulates milk ejection in the breasts and uterine contractions during childbirth.
Oxytocin
Leads to an increase in water absorption in kidneys and a decrease in water lost through urine.
Purpose: help the body hold onto water by concentrating urine.
Antidiuretic Hormone (ADH)
A small region in the brain. Can be thought of as a regulatory control center.
Plays many roles in homeostasis through regulating the release of hormones from the pituitary gland.
hypothalamus
Hormones that induce the release of other hormones from endocrine glands.
Many are produced in the hypothalamus and act on the pituitary, examples: GnRH, CRH.
Tropic hormones
Gonadotropin-releasing hormone (GnRH) in the hypothalamus triggers
GnRH (hypothalamus) → FSH and LH (anterior pituitary) → gonads
Corticotropin-releasing hormone (CRH) in the hypothalamus triggers
CRH (hypothalamus) → ACTH (anterior pituitary) → cortisol (adrenal cortex)
Inhibits release of prolactin from the pituitary and plays a role in the reward pathway.
Dopamine
This brain structure plays a critical role in regulating hunger, temperature, thirst.
Hypothalamus
Mnemonic: HTTP = Hunger, Temperature, Thirst, Pituitary control
Solubility of peptide hormones
water-soluble
Solubility of steroid hormones
lipid-soluble
Permeability of peptide hormones
hydrophilic, cannot diffuse through membranes
Permeability of steroid hormones
hydrophobic, diffuses through membranes
Peptide hormones are made in
Rough ER
Steroid hormones are made in
Smooth ER
Peptide hormones bind to
Extracellular receptors
Steroid hormones bind to
Receptors in the nucleus or cytoplasm
Mechanism of peptide hormones
Triggers signaling cascade of a second messenger inside the cell
Mechanism of steroid hormones
Induces changes in the gene expression
Examples of peptide hormones
Insulin, parathyroid hormone, oxytocine, etc.
Examples of steroid hormones
cortisol, sex hormones