Hormones Flashcards

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1
Q

define the term endocrine glands

A

groups of cells that are specialised to secrete hormones

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2
Q

what are hormones

A

chemical messengers

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3
Q

what are the specific receptors that hormones bind to

A

target cells

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4
Q

why is a hormone called a first messanger

A

it carries the chemical message from the endocrine gland to the receptor on the target cell

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5
Q

why is the signalling molecule called a second messenger

A

carries the chemical message from the receptor to other pars of the cell

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6
Q

describe the effect of adrenaline when it is released

A

adrenaline is a first messenger
binds to target cells
activates enzyme called adenylyl cyclase
this catalyses the production of the second messenger called cAMP from ATP
this activates a cascade of enzyme reactions

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7
Q

what type of hormones does the cortex of the adrenal glands secrete and what do they do

A

steroid hormones (cortisol and aldosterone)
breakdown of proteins and fats into glucose, increases blood volume and pressure , suppresses the immune system

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8
Q

what type of hormones does the medulla of the adrenal glands secrete and what is their effect

A

catecholamine hormones, increase breathing and heart rate so cells break down glycogen

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9
Q

describe the histology of the pancreas

A

the areas of the pancreas that contain endocrine tissue are called the islets of Langerhans, made up of alpha and beta cells

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10
Q

how would you identify islets of Langerhans on a microscope

A

paler patches amongst other cells

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11
Q

what endocrine gland controls blood glucose conc

A

pancreas

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12
Q

what secretes insulin

A

beta cells in the Islets of Langerhans

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13
Q

what secretes glucagon

A

alpha cells in the Islets of Langerhans

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14
Q

how does insulin lower blood glucose conc

A

increases permeability of liver and muscle cells to glucose
activates enzymes that convert glucose into glycogen in a process called glycogenesis

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15
Q

how does glucagon increase blood glucose conc

A

activates enzymes that breaks down glycogen called glycogenolysis
also promotes the formation of glucose from glycerol and amino acids in a process called gluconeogenesis

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16
Q

the regulation of blood glucose conc,. is an example of what

A

negative feedback

17
Q

when beta cells detect high blood conc. changes within the cell result in secretion of insulin how does this work

A

more glucose enters beta cells by facilitated diffusion
this causes rate of respiration to increase, making more ATP
potassium ion channels then close
the ions cant leave so the cell becomes less negative and membrane becomes depolarised
calcium channels then open and ions diffuse into cell
vesicles then fuse with membrane and releases insulin via exocytosis

18
Q

what is type 1 diabetes

A

auto-immune disease where the body attacks beta cells so no insulin is produced and kidneys cannot reabsorb the glucose so some is excreted in the urine

19
Q

how is type 1 diabetes treated

A

with insulin therapy, for some people this includes an insulin pump
some people have been treated with beta cell transplants
carefully planned diet and regular exercise

20
Q

what is type 2 diabetes

A

when beta cells don’t produce enough insulin or cells do not respond properly to insulin

21
Q

how is type 2 diabetes treated

A

regular exercise and a balanced healthy diet
or medication

22
Q

why would treating diabetes with GM bacteria be more beneficial

A

cheaper, larger quantities can be produced, make human insulin rather than having to extract insulin from animals like pigs, ethically better due to religion/ eating preferences

23
Q

how would stem cells be used to treat diabetes

A

stem cells could grow into beta cells which would then be implanted into the pancreas allowing them to produce insulin