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PCOL FINALS > Hormonal Agents: Analogues and Inhibitors (Part 02) > Flashcards

Hormonal Agents: Analogues and Inhibitors (Part 02) Flashcards

1
Q

Drugs that mimic or block the effects of hypothalamic and pituitary hormones have pharmacologic applications in three (3) primary areas: (A) As replacement therapy for hormone deficiency states; (B) As antagonists for diseases caused by excess production of pituitary hormones; (C) As diagnostic tools for identifying several endocrine abnormalities.

A

Hormonal Agents

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2
Q

Two (2) Medicinal GH

A
  1. Somatropin
  2. Somatrem
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3
Q

(T/F): Medicinal GH was isolated from the pituitaries of human cadavers.

A

T

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4
Q

Medicinal GH is contaminated with prions that could cause __________.

A

Creutzfeldt-Jakob Disease

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5
Q

Five (5) Uses of Medicinal GH

A
  1. Prader-Willi Syndrome
  2. Turner Syndrome
  3. Idiopathic Short Stature (ISS)
  4. Anti-Aging Remedy
  5. Use by Athletes
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6
Q

An autosomal dominant genetic disease associated with growth failure, obesity, and carbohydrate intolerance.

A

Prader-Willi Syndrome

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7
Q

Drug/s under Recombinant Human IGF-I / Somatomedins

A
  1. Mecasermin
  2. Mecasermin Rinfabate
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8
Q

Drug/s for the treatment of severe IGF-I deficiency that is not responsive to GH.

A
  1. Mecasermin
  2. Mecasermin Rinfabate
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9
Q

A/E of Recombinant Human IGF-I / Somatomedins

A

Hypoglycemia

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10
Q

Drug/s for Excessive GH

A
  1. Somatostatin
  2. Octreotide
  3. Lanreotide
  4. Pegvisomant
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11
Q

It inhibits the release of GH, TSH, glucagon, insulin, and gastrin.

A
  1. Somatostatin
  2. Octreotide
  3. Lanreotide
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12
Q

A GH receptor antagonist.

A

Pegvisomant

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13
Q

A/E of Somatostatin

A

Hyperglycemia

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14
Q

A/E of Ocreotide and Lanreotide

A
  • Nausea
  • Vomiting
  • Abdominal Cramps
  • Flatulence
  • Steatorrhea Vitamin B12 Deficiency
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15
Q

Four (4) Types of Gonadotropin Analogues

A
  1. Menotropins
  2. FSH Analog
  3. LH Analog
  4. Human Chorionic Gonadotropin
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16
Q

A human menopausal gonadotropins (HMG). It is extracted from the urine of postmenopausal women. The purified extract of FSH and LH.

A

Menotropins

17
Q

A purified preparation of human extracted from the urine of postmenopausal women.

A

Urofollitropin

18
Q

Two (2) Recombinant Forms of FSH

A
  1. Follitropin Alfa
  2. Follitropin Beta
19
Q

Recombinant Form of Human LH

A

Lutropin Alfa

20
Q

It has only been approved for use in combination with follitropin alfa for stimulation of follicular development in infertile women with profound LH deficiency.

A

Lutropin

21
Q

It is produced by the human placenta and excreted into the urine.

A

Human Chorionic Gonadotropin

22
Q

An acetate salt of synthetic human GnRH.

A

Gonadorelin

23
Q

Drug/s under GnRH Agonists

A
  1. Goserelin
  2. Histrelin
  3. Leuprolide
  4. Nafarelin
  5. Triptorelin
24
Q

A syndrome of cyclical abdominal pain in premenopausal women that is due to the estrogen-sensitive endometrium-like tissue in the uterus.

A

Endometriosis

25
Q

Drug/s under GnRH Antagonists

A
  1. Ganirelix
  2. Cetrorelix
  3. Degarelix
26
Q

Drug/s under Synthetic Estrogen

A
  1. Ethinyl Estradiol
  2. Diethylstilbestrol
27
Q

Drug/s for Anti-Estrogen

A
  1. Estrogen Receptor Blockers
  2. SERMs
  3. Aromatase Inhibitor
28
Q

Drug/s under Estrogen Receptor Blockers

A
  1. Tamoxifen (Nolvadex)
  2. Clomiphene (Clomid)
29
Q

Drug/s under SERMs

A

Raloxifene (Evista)

30
Q

Drug/s under Aromatase Inhibitor

A
  1. Anastrazole (Arimidex, Anazole)
  2. Letrozole (Femara)
31
Q

Drug/s under Synthetic Progesterone / Progestins

A
  1. Levonorgestrel
  2. Norethindrone
  3. Medroxyprogesterone
32
Q

A Progestin Antagonist

A

Mifepristone

33
Q

A synthetic, or human-made, variations of the male sex hormone testosterone.

A

Synthetic Testosterone / Anabolic Steroids

34
Q

Drug/s under Synthetic Testosterone / Anabolic Steroids

A
  1. Nandrolone
  2. Oxandrolone
  3. Stanozolol
  4. Trenbolone Acetate
35
Q

Treatment of Hyperprolactinemia

A
  1. Ergot Alkaloids
    • Bromocriptine
    • Cabergoline
    • Pergolide
  2. Nonergot
    • Quinagolide

PCOL FINALS (9 decks)

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