HIV trivia

Question 1

Life cycle of HIV

Answer 1

1) attachment to CD4 and coreceptor
2) Fusion
3) Penetration of contents into cell
4) Reverse transcription (reverse transcriptase)
5) integration of viral DNA into host DNA (integrase)
6) Transcription
7) Assembly
8) Budding
9) Maturation (protease)

Question 2

HIV tropism

Answer 2

HIV lives and replicates in CD4 cells.

Question 3

Stages of HIV infection

Answer 3

Acute
Seroconversion (3-4 wks)
Asymptomatic (5-10yrs)
Symptomatic (fatigue, weight loss...)
AIDS

Question 4

Metaphor for progression to AIDS

Answer 4

Viral load= speed of train

CD4 count= length of track remaining

Question 5

CD4 counts associated with infection

Answer 5

<50: MAC

Any count: TB

Question 6

HIV-related cancers

Answer 6

lymphoma, cervical, kaposi’s sarcoma

Question 7

When are ARV’s usually given?

Answer 7

CD4<500

Question 8

Types of ARVs

Answer 8

• protease inhibitors
• fusion inhibitors
• integrase inhibitor
• NNRTIs (non-nucleoside reverse transcriptase inhibitors)
• NRTI (nucleoside reverse transcritase inhibitors)