Histopathology of Acute Myocardial Infarction

Question 1

24 -48 hours after onset of symptoms

Answer 1

macro - Pale, oedematous muscle

micro - Oedema, neutrophil
infiltration, necrosis of myocytes

Question 2

3-4 days after onset of symptoms

Answer 2

macro - Yellow, rubbery centre with haemorrhagic border

micro - Obvious necrosis and inflammation: early granulation tissue

Question 3

1-3 weeks after onset of symptoms

Answer 3

macro - Infarcted area paler and thinner than unaffected ventricle

micro - Granulation tissue then progressive fibrosis

Question 4

3-6 weeks

Answer 4

macro - Silvery scar becoming tough and white

micro - dense fibrosis