Histology of the male reproductive system Flashcards

1
Q

what is the role of the testes?

A

sperm and androgen production

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2
Q

what is the role of the epididymis, ductus defers, ejaculatory duct, and the urethra?

A

sperm transport

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3
Q

what is the role of the seminal vesicles, prostate gland, and the bulbourethral glands?

A

semen production and sperm nutrient source

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4
Q

what is the role of the penis?

A

copulatory organ with erectile tissue

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5
Q

what is the name of the dense connective tissue capsule surrounding the testes?

A

the tunica albuginea

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6
Q

what is the network of fibrous connective tissue that is located on the posterior side of the testes that extends from the top to the bottom of each teste?

A

the mediastinum testis

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7
Q

what is house within each lobule that the septa creates?

A

the seminiferous tubules

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8
Q

where exactly does sperm production take place in the testes?

A

the seminiferous tubules

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9
Q

what is the tunica vaginalis derived from?

A

the peritoneum

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10
Q

how can the tunica vaginalis be divided?

A

into an outer parietal layer that is lining the scrotum and an inner visceral layer that is covering the tunica albuginea

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11
Q

what are the retentions testis?

A

a series of tubes that relay sperm out of the efferent ductules to reach the epididymis

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12
Q

what are the seminiferous tubules lined with?

A

seminiferous epithelium

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13
Q

what are the 2 cell types found within the seminiferous tubules?

A

the Sertoli cells and the spermatogenic cells

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14
Q

what are the seminiferous tubules surrounded by and what is the function?

A

they are surrounded by connective tissue and 3-5 layers of flattened peritubular myoid cells; they create peristaltic contractions that help move the spermatozoa

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15
Q

what cells are found in between the seminiferous tubules?

A

the interstitial cells of leydig

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16
Q

how can the interstitial cells of leydig be described?

A

they are steroid-producing cells (testosterone) containing lipid droplets, mitochondria, and a well-developed sER

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17
Q

what are the interstitial cells of leydig accompanied by?

A

myoid cells and fibroblasts

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18
Q

what kind of epithelium makes up the seminiferous epithelium?

A

stratified epithelium with unusual characteristics

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19
Q

what kind of cells are sertoli cells?

A

columnar cells with extensive processes

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20
Q

what is the hallmark of sertoli cells?

A

the cyclops nucleus

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21
Q

what is the most immature form of spermatogenic cells?

A

the spermatogonia

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22
Q

where are spermatogonia cells found?

A

they rest on the basal lamina

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23
Q

what is the most mature form of spermatogenic cell?

A

spermatids

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24
Q

where are the spermatids found?

A

they are attached to the apical portion of the sertoli cells near the tubule lumen

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25
Q

what cell population forms the blood-testis-barrier?

A

sertoli cells

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26
Q

how is the blood-testis-barrier established?

A

the sertoli cells are bound by tight junctions to form the sertoli-cell-to-certoli-cell junctional complex

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27
Q

what does the blood-testis-barrier prevent?

A

the attack of the haploid sperm- it significantly decreases permeability

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28
Q

what is found below the blood-testis-barrier?

A

the basal compartment

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29
Q

what is the basal compartment?

A

an open space below the junctional barrier that is adjacent to the basement membrane but also adjacent to the circulation to the testis

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30
Q

what is found above the blood-testis-barrier?

A

the luminal compartment

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31
Q

what is the luminal compartment?

A

the compartment that is exposed to the lumen of the seminiferous tubules

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32
Q

once cells pass from the basal compartment to the luminal compartment, what are they protected from?

A

any immunological response that could occur in the circulation

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33
Q

what happens when type a spermatogonia undergo mitosis?

A

it will generate a copy of itself or a type B spermatogonia

34
Q

what happens to type B spermatogonia?

A

it will enter into meiosis and change–> it will divide to form a primary spermatocyte

35
Q

where do the spermatocytes undergo two meiotic divisions?

A

inside the blood-testes barrier (beyond the point of being exposed to the circulating blood)

36
Q

what happens when the primary spermatocyte divides?

A

it will form a secondary spermatocyte

37
Q

what happens when the secondary spermatocyte divides?

A

it forms the spermatids

38
Q

what are the haploid germ cells that are located in the seminiferous compartments (specifically the luminal compartment)?

A

secondary spermatocytes, spermatids, and sperm

39
Q

what cells are restricted to the basal compartment?

A

spermatogonia and early primary spermatocytes

40
Q

what cell types pass through the junctional complex and move from the basal to the luminal compartment by breaking up the junctions?

A

the primary spermatocytes

41
Q

what cell types are restricted to the luminal compartment?

A

mature spermatocytes and spermatids

42
Q

what cells undergo spermatogenesis and differentiate into mature sperm cells?

A

spermatids

43
Q

where are the round (early) spermatids housed?

A

in niches of sertoli cells

44
Q

where are the elongated (late) spermatids housed?

A

in the apical crypts of the sertoli cells

45
Q

what is spermiation?

A

the release of mature spermatids into the lumen

46
Q

what piece of the sperm tail contains the mitochondria?

A

the middle piece

47
Q

what is the longest piece of the sperm tail called?

A

the principal piece

48
Q

what is the sperm transport pathway starting with the straight tubules?

A

straight tubules–> rete testis–>efferent ductules–>epididymis–> ductus deferens–> ejaculatory duct

49
Q

where do sperm mature?

A

in the epididymis

50
Q

what is the tissue type of the epididymis?

A

pseudostratified columnar epithelia with long sterocilia

51
Q

what 2 cell types make up the epididymis?

A

the principal cells and the stem cells

52
Q

what does sperm maturation consists in acquiring?

A

forward motility

53
Q

what part of the epididymis are mature sperm stored in?

A

the tail

54
Q

what is the ductus deferens lined with?

A

pseudostratified columnar epithelia with sparse stereocilia

55
Q

what is the ductus deferens supported by?

A

a CT lamina propria with elastic fibers

56
Q

what is the musculature of the ductus deferens like?

A

inner and outer longitudinal layers and a middle circular layer

57
Q

what is the ampulla of the ductus deferens?

A

it is the dilated portion that leads directly into the prostate gland

58
Q

what does the distal end of the ductus deferens receive?

A

the ducts of the seminal vesicles, which forms the ejaculatory ducts

59
Q

what are the accessory glands of the male reproductive system?

A

seminal vesicles (2), prostate gland (1), bulbourethral glands (2), and the urethral glands

60
Q

which accessory glands produce the majority of the seminal fluid?

A

the seminal vesicles and the prostate gland

61
Q

what is the function of the accessory glands regulated by?

A

androgens (testosterone and DHT)

62
Q

what is the composition of fluid secreted by the seminal vesicles?

A

it is an alkaline secretion that is rich in fructose and prostaglandins

63
Q

what do the seminal vesicles look like histologically?

A

highly folded mucosa lined by pseudostratified columnar epithelium; no sterocilia

64
Q

what are the different zones of the prostate gland?

A

the central zone, the peripheral zone, the transitional zone, and the periurethral zone

65
Q

what does the central zone of the prostate gland surround?

A

the ejaculatory ducts as they pierce the prostate gland

66
Q

what does the peripheral zone of the prostate gland surround?

A

the central zone and the posteriolateral parts of the gland; it is palpable during a digital rectal exam

67
Q

where do most prostatic carcinomas arise?

A

in the peripheral zone

68
Q

what does the transitional zone of the prostate gland surround?

A

the prostatic urethra (contains mucosal glands

69
Q

what can occur in the transitional zone of the prostate gland?

A

the parenchymal cells undergo hyperplasia and form nodular masses of epithelial cells- this can cause benign prostatic hyperplasia

70
Q

what does the periurethral zone contain?

A

mucosal and submucosal glands

71
Q

in later stages of BPH, which prostate zone can undergo pathologic growth?

A

the periurethral zone

72
Q

what do all the glands empty into?

A

the prostatic urethra

73
Q

what is the prostatic urethra?

A

the end site of the prostatic ducts and ejaculatory ducts

74
Q

what is the prostate gland lined with?

A

simple columnar or pseudostratified epithelium

75
Q

what does the lumen of the prostate gland contain?

A

corpora amylacea

76
Q

what does the prostate gland produce and for what reason?

A

a Zn-rich alkaline fluid, it neutralizes the acidic environment of the vagina

77
Q

what are the pea-sized structures that are located in the urogenital diaphragm and resemble mucous glands?

A

bulbourethral glands

78
Q

what are the bulbourethral glands lined with?

A

simple columnar epithelium that is under the control of testosterone

79
Q

what do the bulbourethral glands secrete?

A

preseminal fluid–> lubricates the penile urethra and neutralizes traces of acidic urine

80
Q

what are the corpora cavernosa of the penis each surrounded by?

A

a dense fibroelastic layer- the tunica albuginea

81
Q

what does erection involve?

A

blood filling the cavernous spaces of the erectile tissues (controlled by the ANS in the vascular walls)