female reproductive histology Flashcards
what are the two coexisting events during the menstrual cycle?
the ovarian cycle and the uterine cycle
what is the ovary lined by?
ovarian surface epithelium (OSE)
what is ovarian surface epithelium?
simple cuboidal epithelium; the embryonic source of granulosa cells and stromal cells
what is the overlying layer of dense connective tissue capsule of the ovary?
the tunica albuginea
how is the ovary structured?
with a peripheral cortex and a deep medulla
what is located in the cortex of the ovary?
connective tissue and ovarian follicles
what is located in the medulla of the ovary?
connective tissue and interstitial cells, neurovasculature, and lymphatics
what do the ovarian follicles contain?
a single oocyte
when do the early stages of oogenesis occur?
during fetal life
what are the oocytes that are present at birth doing?
they are remaining arrested in meiosis I (prophase I)
what occurs during folliculogenesis?
select follicles undergo cyclic growth and maturation
what are primordial follicles surrounded by?
simple squamous layer of follicular/ pregranulosa cells
what are the primary follicles surrounded by?
a simple cuboidal layer of granulosa cells
what separates the granulosa cells from the ovarian stroma?
the basal lamina
when does the zona pelucida begin to assemble and what does it separate?
it begins to assemble at the primary follicle stage and it separates the primary oocyte from the granulosa cells
what surrounded late primary follicles?
stratified granulosa cells (3-4 cells in thickness)
what begins to appear in the secondary follicles?
the granulosa cells begin to secrete a follicular fluid, forming call-exner bodies, which eventually enlarge and combine forming the antrum
during the secondary follicle stage, what do the stromal cells form?
separate thecal layers
what are the two thecal layers that the stromal cells form?
theca interna and theca externa
what epithelium makes up the theca?
stratified cuboidal epithelium
what is the theca interna?
a vascularized cell layer adjacent to the basal lamina supporting the granulosa- main role is to produce androstenedione (which can be converted into estrogen)
what is the theca externa?
a fibrous cellular layer continuous with the ovarian stroma
what do the mural granulosa cells actively synthesize and secrete?
estrogen and they produce the follicular fluid
what is the mechanism of follicular atresia?
apoptosis
what is the hallmark of an atretic follicle?
it will have a glassy membrane: thick folded basement membrane material
what does the LH surge cause?
the primary oocyte to complete meiosis I, making it a secondary oocyte (now arrested at metaphase II)
what cells are responsible for repairing the OSA damage following follicle rupture?
mural granulosa cells and the theca interna
during the luteal phase, what happens to the thecal cells?
they will differentiate to form the corpus luteum
during the luteal phase, what do the mural granulosa cells become?
granulosa lutein cells