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flashcards of path guide 2018 > histo rheum > Flashcards

histo rheum Flashcards

1
Q

histological findings for sarcoid

A

non caseating granulomas asteroid bodies Schaumann bodies

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2
Q

investigations for Sarcoid

A

raised Ca Raised ESR raised ACE Kveim test historically- intradermal injection of splenic sarcoid tissue and resultant granuloma formation

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3
Q

extra pulomary symptoms for sarcoid

A

weight loss night sweats hypercalcaemia/ hypercalciuria arthritis bone cysts erythema nodosum lupus pernio skin nodules ant/ post uveitis uveoparotid fever

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4
Q

what is uveoparotid fever

A

Heerfordt syndrome facial palsy bilateral uveitis parotid enlargment

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5
Q

amyloidosis

A

multisystem disease where misfolded proteins are deposited as fibrils in healthy tissue

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6
Q

primary amyloidosis protein

A

amyloid L

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7
Q

secondary amyloidosis protein

A

amyloid A

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8
Q

secondary amyloidosis associations

A

RA, ank spond TB renal cell carcinoma hodgkin lymphoma

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9
Q

familial amyloidosis alternative name

A

familial mediterranean fever

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10
Q

defect in familial mediterranean fever

A

pyrin gene overproduction of IL1

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11
Q

protein in haemodialysis associated amyloidosis

A

beta 2 microglobulin

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12
Q

diagnosis of amyloidosis

A

apple green bifringence under polarised light witha congo red stain

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13
Q

what causes the findings under polarised light in amyloidosis

A

beta sheets and the fibrils self assort as they are unstable

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14
Q

symptoms of amyloidosis

A

nephotic syndrome cardiac arrythmia carpal tunnel hepatosplenomegaly macroglossia in 10%

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15
Q

what are the large vessel vasculitides

A

temporal arteritis takayasu’s arteritis

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16
Q

who gets takayasu’s arteritis

A

middle aged japenese women

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17
Q

sx of takayasu’s arteritis

A

bruits pulseless disease claudications

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18
Q

temporal arteritis symptoms

A

jaw claudication scalp tenderness raised ESR

19
Q

histology of temporal arteritis

A

granulomatous transmural inflammation

20
Q

WHAT IS SEEN ON ANGIOPATHY OF POLYARTERITIS NODOSA

A

MICROANEURYSMS

21
Q

what disease predisposes you to PAN

A

hep B

22
Q
A
23
Q

SLE reaction type

A

type 3 hypersesitivity

24
Q

autoantibodies in SLE

A

anti dsDNA antism anti histone ANA

25
Q

hisotlogy of SLE

A

lupus erythematosus cell onion skin lesion in splenn libman sacks endocarditis microangiopathy in CNS

26
Q

symptoms of SLE 4 of SOAP BRAIN MD

A

serositis Oral ulcers Arthritis Photosensitivity Blood disorders e.g. AIHA,lecopenia, ITP Renal involvment ANA +ve Immune pheonomena e..g antidsDNA ab Neuro sx malar rash discoid rash

27
Q

HLA association ion SLE

A

HLA DR3 (or2)

28
Q

HLA association for limited or diffuse scleroderma

A

HLA DR5 and DRw8

29
Q

autoantibodie in limited scleroderma

A

anti centromere

30
Q

sx oflimited scleroderma

A

calcinosis raynauds oesophageal dysmotility Sclerodactyly telangectasia pulm HTN

31
Q

histology of limited scleroderma

A

onion skinning of arteries increased collagen in skin and organs

32
Q

autoantibodies in diffuse scleroderma

A

anti scl-70 fibrillarin RNA polyermase I, II, III PM-Scl

33
Q

histology of diffuse scleroserma

A

inflammation within and around muscle fibres

34
Q

sx of diffuse scleroderma

A

skin and organ changes pulmonary fibrosis

35
Q

dermatomyositis and polymyositis autoantibody

A

anit-Jo1

36
Q

whatis anti Jo1

A

tRNA synthase

37
Q

polymyositis histology

A

endomysial inflammatoary infiltrate

38
Q

dermatomyositis histology

A

capilliary and myofibre damage

39
Q

sx of dermatomyositis and polymyositis

A

proximal muscle weakness abnormal EMG raised CK

40
Q

dermatomyositis cutaneous features

A

gotten papules on hands heliotrope rash on eyes

41
Q

what is associated with dermatomyositis and polymyositis

A

underlying malignancy

42
Q

what condition is associated with dermatomyositis

A

pulmonary fibrosis

43
Q

difference between pemphigus and pemphigoid

A

pemphigoid forms subepidermal bullae and pehmigus forms intraepidermal IgG is linier in pemphigoid and netlike in pemphigus in pemphigoid the IgG binds to intercellular hemi desmosomes onBM whereas in pemphigus the IgG binds to demosomal proeteins

flashcards of path guide 2018 (15 decks)

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