histo rheum Flashcards
histological findings for sarcoid
non caseating granulomas asteroid bodies Schaumann bodies
investigations for Sarcoid
raised Ca Raised ESR raised ACE Kveim test historically- intradermal injection of splenic sarcoid tissue and resultant granuloma formation
extra pulomary symptoms for sarcoid
weight loss night sweats hypercalcaemia/ hypercalciuria arthritis bone cysts erythema nodosum lupus pernio skin nodules ant/ post uveitis uveoparotid fever
what is uveoparotid fever
Heerfordt syndrome facial palsy bilateral uveitis parotid enlargment
amyloidosis
multisystem disease where misfolded proteins are deposited as fibrils in healthy tissue
primary amyloidosis protein
amyloid L
secondary amyloidosis protein
amyloid A
secondary amyloidosis associations
RA, ank spond TB renal cell carcinoma hodgkin lymphoma
familial amyloidosis alternative name
familial mediterranean fever
defect in familial mediterranean fever
pyrin gene overproduction of IL1
protein in haemodialysis associated amyloidosis
beta 2 microglobulin
diagnosis of amyloidosis
apple green bifringence under polarised light witha congo red stain
what causes the findings under polarised light in amyloidosis
beta sheets and the fibrils self assort as they are unstable
symptoms of amyloidosis
nephotic syndrome cardiac arrythmia carpal tunnel hepatosplenomegaly macroglossia in 10%
what are the large vessel vasculitides
temporal arteritis takayasu’s arteritis
who gets takayasu’s arteritis
middle aged japenese women
sx of takayasu’s arteritis
bruits pulseless disease claudications
temporal arteritis symptoms
jaw claudication scalp tenderness raised ESR
histology of temporal arteritis
granulomatous transmural inflammation
WHAT IS SEEN ON ANGIOPATHY OF POLYARTERITIS NODOSA
MICROANEURYSMS
what disease predisposes you to PAN
hep B
SLE reaction type
type 3 hypersesitivity
autoantibodies in SLE
anti dsDNA antism anti histone ANA
hisotlogy of SLE
lupus erythematosus cell onion skin lesion in splenn libman sacks endocarditis microangiopathy in CNS
symptoms of SLE 4 of SOAP BRAIN MD
serositis Oral ulcers Arthritis Photosensitivity Blood disorders e.g. AIHA,lecopenia, ITP Renal involvment ANA +ve Immune pheonomena e..g antidsDNA ab Neuro sx malar rash discoid rash
HLA association ion SLE
HLA DR3 (or2)
HLA association for limited or diffuse scleroderma
HLA DR5 and DRw8
autoantibodie in limited scleroderma
anti centromere
sx oflimited scleroderma
calcinosis raynauds oesophageal dysmotility Sclerodactyly telangectasia pulm HTN
histology of limited scleroderma
onion skinning of arteries increased collagen in skin and organs
autoantibodies in diffuse scleroderma
anti scl-70 fibrillarin RNA polyermase I, II, III PM-Scl
histology of diffuse scleroserma
inflammation within and around muscle fibres
sx of diffuse scleroderma
skin and organ changes pulmonary fibrosis
dermatomyositis and polymyositis autoantibody
anit-Jo1
whatis anti Jo1
tRNA synthase
polymyositis histology
endomysial inflammatoary infiltrate
dermatomyositis histology
capilliary and myofibre damage
sx of dermatomyositis and polymyositis
proximal muscle weakness abnormal EMG raised CK
dermatomyositis cutaneous features
gotten papules on hands heliotrope rash on eyes
what is associated with dermatomyositis and polymyositis
underlying malignancy
what condition is associated with dermatomyositis
pulmonary fibrosis
difference between pemphigus and pemphigoid
pemphigoid forms subepidermal bullae and pehmigus forms intraepidermal IgG is linier in pemphigoid and netlike in pemphigus in pemphigoid the IgG binds to intercellular hemi desmosomes onBM whereas in pemphigus the IgG binds to demosomal proeteins
