Histo: Follicular Development Flashcards

1
Q

Before birth what is happening to the egg cells?

A

mitosis

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2
Q

During childhood, what stage are the egg cells arrested in?

A

Meiosis 1

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3
Q

Monthly after puberty, what stage are the egg cells arrested in and what happens if thye become fertilized?

A

Arrested in Meiosis 2 (get period)

If fertilized –> Meiosis 2 completed

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4
Q

Primary oocytes in primordial follicles are arrested @ what stage?

A

Prophase 1

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5
Q

What are the two coexisting events during the menstrual cycle?

A

Ovarian Cycle (houses a primary oocyte)

Uterine Cycle (Endometrium prepares for implantation)

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6
Q

What covers the ovary?

A

Ovarian surface epithelium w/ dense CT layer (tunica albuginea

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7
Q

What are the 3 phases of folliculogenesis?

A

1. Follicular phase (making mature follicle bigger)

  1. Ovulatory Phase
  2. Luteal phase
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8
Q

What are follicular cells?

A

Single layer of cells that surround a primodial follicle

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9
Q

What are granulosa cells?

A

Folliclular cells that proliferate and become stratified

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10
Q

What do granulose cells eventually segregate into?

A
  1. cumulus oophorous
  2. mural granulosa cells
  3. corona radiata
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11
Q

What is the zona pellucida?

A

A case of glycoproteins that encases the primary oocyte and recognizes sperm

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12
Q

What forms the outer covering (theca) of the follicle?

A

Ovarian stromal cells

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13
Q

Theca interna

Theca externa

A

interna –> steroid producing

externa –> fibroblasts + smooth muscle

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14
Q

What is a secondary oocyte?

A

cells that enter meiosis 2 but arrest @ metaphase 1

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15
Q

What is a primary oocyte?

A

cells that have begun the 1st meiotic division, but are arrested @ prophase 1

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16
Q

What is this?

A

Primordial follicle

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17
Q

What is this?

A
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18
Q

What is this?

A

Late primary follicle

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19
Q

What is this?

A

Secondary Follicle

20
Q

What cell type has Call-Exner bodies?

A

Secondary follicles

These are small intercular spaces that contain follicular fluid

21
Q

What is this?

A

Mature (Graffian) Follicle

22
Q

What is this?

A

Mature Follicle

23
Q

What is this?

A

Corpus Luteum

24
Q

What is luteolysis?

A

When there is no fertilization so the sorpus luteum degrades into the corpus albicans

25
Q

What is this?

A

Corpus Albicans (scar tissue)

26
Q
A
27
Q

What is follicular atresia?

A

Failure of a follicle to ovulate

Accomplished via apoptosis

28
Q

What is the oviduct?

A

The arms of the uteurs that catch the ovulated secondary oocyte and transport it to the uterus

29
Q

What are the regions of the oviduct?

A

Infundibulum w/ Fimbriae

Ampulla + Isthmus (lined by mucosal folds)

Intramural

30
Q

What does the wall of the oviduct look like?

A
31
Q

What is this?

A

Oviduct Mucosa

32
Q

What are the 3 layers of the uterus?

A
  1. Endometrium (functional + basal layer)
  2. Myometrium (stratum vasculature)
  3. Perimetrium
33
Q

Straight segment of arcuate arteries supplies what layer of endometrium in the uterus?

A

basal layer

coiled = functional layer

34
Q

What are the 4 phases of the menstrual cycle?

A
  1. Proliferative phase
  2. Secretory Phase
  3. Ischemic Phase
  4. Menstrual Phase
35
Q

What phase of the menstrual cycle is this?

A

Proliferative Phase

  • functional layer = thin
  • stroma more cellular

glands = straight

36
Q

What phase of the menstrual cycle is this?

A

Secretory Phase

-tubular, convoluted glands

-lacunae = widespread + filled with blood

37
Q

What phase of the menstrual cycle is this?

A

Ischemic Phase

  • constriction of spiral arteries
  • sponge like
38
Q

Which layer of the endometrium sloughs off as menstrual flow?

A

Functional Layer

Signals Day 1 of BOTH ovarian + uterine cycle

39
Q

If pregnancy takes place, what cells increase in size to provide an immune-protective environment and moderate syncytiotrophoblast invasion for the embryo?

A

Decidual cells via decidual reaction

Due to increased progesterone

40
Q

What cell type is ectocervix made of?

A

Nonkeratinized stratified squamous epithelium

41
Q

What cell type is the endocervix and cervical crypts?

A

simple columnar cells

42
Q

What is this?

A

Transformation zone between endocervix and ectocervix (larger)

43
Q

What are the 3 layers of the vagina?

A
  1. Mucosal layer
  2. Muscularis layer
  3. Adventitial layer
44
Q

What is this?

A

Vagina

45
Q

What is this?

A

Labia majora (sebecous glands/ducts)

mons pubis –> has hair follicles