Histo: Follicular Development Flashcards
Before birth what is happening to the egg cells?
mitosis
During childhood, what stage are the egg cells arrested in?
Meiosis 1
Monthly after puberty, what stage are the egg cells arrested in and what happens if thye become fertilized?
Arrested in Meiosis 2 (get period)
If fertilized –> Meiosis 2 completed
Primary oocytes in primordial follicles are arrested @ what stage?
Prophase 1
What are the two coexisting events during the menstrual cycle?
Ovarian Cycle (houses a primary oocyte)
Uterine Cycle (Endometrium prepares for implantation)
What covers the ovary?
Ovarian surface epithelium w/ dense CT layer (tunica albuginea
What are the 3 phases of folliculogenesis?
1. Follicular phase (making mature follicle bigger)
- Ovulatory Phase
- Luteal phase
What are follicular cells?
Single layer of cells that surround a primodial follicle
What are granulosa cells?
Folliclular cells that proliferate and become stratified
What do granulose cells eventually segregate into?
- cumulus oophorous
- mural granulosa cells
- corona radiata
What is the zona pellucida?
A case of glycoproteins that encases the primary oocyte and recognizes sperm
What forms the outer covering (theca) of the follicle?
Ovarian stromal cells
Theca interna
Theca externa
interna –> steroid producing
externa –> fibroblasts + smooth muscle
What is a secondary oocyte?
cells that enter meiosis 2 but arrest @ metaphase 1
What is a primary oocyte?
cells that have begun the 1st meiotic division, but are arrested @ prophase 1
What is this?
Primordial follicle
What is this?
What is this?
Late primary follicle