Histo 5 The integument

Question 1

Merocrine vs holocrine vs apocrine

Answer 1

Question 2

Keratinization and desquamation

Answer 2

Question 3

Stratum Basale

Answer 3

Question 4

sebaceous glands produce what?

Answer 4

sebum via holocrine secretion

(descharged in to infundibulum forming pilosebaceous canal)

Question 5

Why is melanoma spread so easily?

Answer 5

Neural crest cells so cancer mutation can turn on old neural crest cell mechanism of migration

Question 6

sebaceous gland

Answer 6

Question 7

merkel cells

Answer 7

Question 8

what does filaggrin do?

Answer 8

promotes aggregation of keratin fibers (tonofibrils)

Question 9

Melanocytes

Answer 9

Question 10

Reticular layer

Answer 10

Question 11

Dermal-epidermal junction

Answer 11

Question 12

Melanosome does what?

Answer 12

• extend into cell processes
• transferred to keratinocytes via phagocytosis

(Pigment donation)

Question 13

Papillary layer

Answer 13

Question 14

Stratum corneum

Answer 14

Question 15

what creates tight interface between dermis and epidermis?

Answer 15

Hemidesmosomes

Question 16

Langerhans cells

Answer 16

Question 17

Pacinian corpuscle

Answer 17

Question 18

Keratinocytes

Answer 18

Question 19

Apocrine sweat glands

Answer 19

Question 20

what are the layers of dermis?

Answer 20

Papillary layer

reticular layer

Question 21

Hypodermis

Answer 21

(subcutaneous fascia)

not integument but is connected to it

Question 22

Where does melanin production take place?

Answer 22

• Premelanosomes= membrane-bound organelles
• more melanin produced they turn into melanosome

Question 23

Stratum granulosum

Answer 23

Question 24

Free nerve endings

Answer 24

Question 25

Sweat (sudoriferous) glands

Answer 25

classified by structure and nature of their secretion * Eccrine (merocrine) sweat glands * coiled around whole body * except lips and external genitalia * Apocrine sweat glands * axilla, arreola, skin anus, external gen * glands of ear canal (ceruminous)

Question 26

integument provides what?

Answer 26

* protection (physical, chemical, and biological * sensation and excretion * thermoregulation * synthesis of vitamin D3

Question 28

What molecule is made into melanin and what are the intermediates?

Answer 28

* Oxidation of tyrosine into DOPA * Via tyrosinase * DOPA polymerized into melanin * (enzyme is UV sensitive)

Question 29

What are eccrine sweat glands duct surrounded by?

Answer 29

stratified cuboidal

Question 30

Layers of the epidermis (superficial to deep)

Answer 30

* Stratum Corneum (SC) * Stratum Lucidum * Stratum Granulosum (SGr) * Stratum spinosum (SS) * Stratum Basale (SB)

Question 31

Stratum lucidum

Answer 31

Question 32

Eccrine sweat glands

Answer 32

Question 33

Epidermal differentiation and replacement

Answer 33

* Epidermal cell replacement initiated by division of stem cells in stratum basale * new cells undergo divisions in Stratum basale * move upward as they differentiate into keratinized cells * eventually are lost by exfoliation on skin surface

Question 34

What is the epidermis comprised of?

Answer 34

* Keratinocytes * melanocytes * Merkel cells * Langerhans cells

Question 35

what are Langerhans cells derived from?

Answer 35

Monocyte precursor

Question 36

Meissner's corpuscle

Answer 36

Question 37

Thick skin vs thin skin

Answer 37

Question 38

Stratum spinosum

Answer 38