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MSK II > Histo 1 Connective Tissues Fibrous > Flashcards

Histo 1 Connective Tissues Fibrous Flashcards

1
Q

What is Marfan’s syndrome?

A
  • Autosomal dominant disorder where elastin is weak
  • occular, skeletal, and cardiovas sytems
  • life threatening (from cardiovas)
  • tall long arms/legs
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2
Q

Adipose CT characteristic and locations?

A
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3
Q

functions of Connective tissues?

A
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4
Q

Structure?

A

Fibroblast

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5
Q

Dense regular CT function?

A
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6
Q

Fibroblast function

A
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7
Q

Fixed cells vs wandering cells

A
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8
Q

Dense irregular function and location?

A
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9
Q

What are CT cells separted by?

A

Extracellular matrix.

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10
Q

extracellular proenzyme

A

amorphous ground substance

needs to be activated

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11
Q

Proteoglycans

A
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12
Q

Embryonic Connective tissue

A
  • Rich in ECM (more ECM than cells)
  • Rich in Mesenchymal stem cells
  • some collagen or reticular fibers (not many)
  • in umbilical cord (wartons jelly)
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13
Q

what causes Marfan’s syndrome?

A

mutation in fibrillin-I gene (component of elastin fibers)

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14
Q

Plasma cells

A

differentiate from B- lymphocytes

produce antibodies that mediate immunity

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15
Q

The different fibrous components of ECM of connective tissues

A
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16
Q

Is connective tissue normally exposed to the outside environment?

A

No, it is normally separated by epithelium

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17
Q

What are the types of fibrous connective tissue classes?

A

Loose connective tissue

and

dense connective tissue

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18
Q

Scurvy and CT

A

vitamin C deficiency leads to

deficiency in co-factor in cross-linking collagen fibers

Weakens CT

19
Q

what does ECM carry?

A

oxygen, CO2, nutrients, and wastes

20
Q

glycoproteins

A
21
Q

elastic CT

A
22
Q

White vs brown fat?

A
23
Q

ECM amorphous ground substance types?

A
  • Proteoglycans
  • hyaluronan
  • glycoproteins
  • extracellular proenzymes
24
Q

tissue?

A

dense regular CT

25
Q

Hyaluronan

A

(hyaluronic acid)

26
Q

Types of CT cells? (examples)

A
27
Q

Type of CT?

A

Loose Areolar CT

28
Q

Type-1 collagen fibers?

A
  • aligned and crosslinked to increase tensile strength
  • Banding observed (fibril alignment)
  • 2 alpha type 1 and a alpha type 2
29
Q

Adult Mesenchymal Stem cells

A

are multipotent stem cells that differentiate into:

  • fibroblasts
  • muscle cells (smooth/skeletal)
  • osteoblasts
  • chondroblasts
  • adipocytes
30
Q

What is this tissue?

A

Reticular Connective Tissue

31
Q

Macrophages?

A

differentiate from blood monocyte

phagocytosis and destruction of

  • bacteria
  • damaged or sick cells
  • cell debris

antigen processing and presentation

32
Q

Tissue?

A

Elastic CT

33
Q

Types of loose connective tissue?

A
34
Q

Different major groups of CT?

A
  • Embryonic CT
  • Adult CT
    • fibrous CT
      • loose (Areolar CT)
      • Dense regular
      • dense irregular
  • special: adipose, cartliage, bone, hematopoeitic
35
Q

Loose connective tissue function and location?

A
36
Q

What is this?

A

adipose tissue

(i believe white and brown)

37
Q

Types of Dense connective tissue?

A
38
Q

What is reticular connective tissue function and location?

A
39
Q

Look up structure difference of

Mast Cells

plasma cells

Macrophages

A
40
Q

Mast cells

A

secrete chemicals such as

histamine that mediate the allergic response

and

heparin (anti-coagulant of blood)

resembe baso/eosinophils

41
Q

Ehlers-Danlos Syndrome

A

abnormal collagen synthesis leads to weak collagen fibers (multiple forms). (mutation in the enzymes that make collagen)

42
Q

What is ground substance?

A

extracellular matrix- gel like substance embedded with protein fibers (can be hard and mineralized in bone)

43
Q

Tissue?

A

Dense irregular connective tissue

MSK II (20 decks)

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