Histo 3 Cartilage histology

Question 1

Cartilage overview

Answer 1

Question 2

cartilage components

Answer 2

Cells:

• Chondroblasts
• chondrocytes

Matrix:

• compartmentalized (territorial vs. interterritorial matrix)
• fibers
• ground substance composed of proteoglycans

Question 3

what are Chondroblasts?

Answer 3

Cells that secrete cartilage matrix

(mitotic capabilities)

Question 4

what are Chondrocytes?

Answer 4

mature cartilage cells in lacunae

(surrounded by and maintain matrix)

Question 5

What fibers are present?

Answer 5

• Type II collagen is predominant
• Type I collagen is present in fibrocartilage and outer perichondrium
• elastin fibers in elastic cartilage

Question 6

Types of ground cartilage?

Answer 6

Proteoglycans:

• Hyaluronic acid
• chondroitin sulfate
• keratin sulfate
• aggrecan

Question 7

Types of cartilage

Answer 7

Hyaline

Elastic

fibrocartilage

Question 8

Hyaline cartilage

and location

Answer 8

• surrounded by perichondrium (except articular)
• contains type II collagen
• gel-like (amorphous but homogeneous)

Location

• articular cartilage
• larynx
• trachea
• ribs
• embryonic development

Question 9

Elastic cartilage

Location

Answer 9

More bendable and recoil to original position

Hyaline PLUS elastic fibers in matrix

surrounded by perichondrium

type II collagen

Location:

• External ear
• epiglottis
• auditory tube

Question 10

Fibrocartilage

location

Answer 10

Needs greater strength (type 1)

Location:

• intervertebral discs
• pubic symphysis
• TMJ

Question 11

Answer 11

Hyaline cartilage

Question 12

cartilage matrix

Territorial matrix

Answer 12

Moderately staining

type II collagen random arrange (less amount)

Question 13

cartilage matrix

interterritorial matrix

Answer 13

Surrounds territorial matrix

less intensely stained

more collagen II

fewer proteoglycans

Question 14

What are the red arrows pointing to?

Answer 14

red= interterritorial matrix

red+black= territorial matrix

Question 15

What is perichondrium?

Answer 15

• Dense irregular CT
• contains vascular supply
• hyaline and elastic cartilage
• source of new cartilage cells
• 2 layers

Question 16

Explain the layers of perichondrium

Answer 16

Fibrous layer: outer layer that produce type I collagen and elastin

(transitional zone between cartilage and surrounding general CT)

Chondrogenic layer: inner layer that differentiates into chondroblasts

secretes type II collagen

Question 17

Answer 17

Elastic cartilage

Question 18

Answer 18

1. perichondrium (fibrous layer)
2. perichondrium (chondrogenic layer)

Question 19

Answer 19

fibrocartilage with a C for chondrocyte

Question 20

Chondrogenesis growth types

Answer 20

Appositional growth

interstitial growth

Question 21

Appositional growth

Answer 21

Question 22

Interstitial growth

Answer 22

Question 23

Synovial joints comprised of

Answer 23

Synovial membrane

articular capsule

articular cartilage

Question 24

Synovial membrane

Answer 24

Question 25

Articular capsule

Answer 25

Question 26

Articular cartilage

Answer 26

Question 27

synoviocytes

Answer 27

Make up synovial membrane

• Type A macrophage-like synovial cells
• Type B fibroblast-like synovial cells

Question 28

Type A macrophage like synovial cells

vs

Type B fibroblast like synovial cells

Answer 28

Question 29

articular cartilage

and its layers?

Answer 29

Question 30

Superficial zone

(articular cartilage)

Answer 30

Question 31

Intermediate zone

(articular cartilage)

Answer 31

Question 32

Deep zone

(articular cartilage)

Answer 32

Question 33

Calcified zone

(articular cartilage)

Answer 33

Question 34

Answer 34

Question 35

Osteoarthritis

Answer 35