Hiperplasia endomentrial Flashcards

1
Q

Definición hiperplasia endometrial

A

Conjunto heterogéneo de lesiones patológicas desde proliferaciones reversibles hasta lesiones precursoras de cáncer.
Proliferación glandular con forma y tamaño irregular con aumento en la relación glándula/estroma del endometrio.

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2
Q

Factores de riesgo (10)

A
  1. Edad >70ª *
  2. Obesidad *
  3. PCOS
  4. Tamoxifeno *
  5. Nuliparidad
  6. Tx con estrógenos *
  7. DM
  8. Menopausia tardía
  9. Sd. Lynch
  10. Sd. Cowden
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3
Q

Factores protectores (4)

A
  1. ACOS
  2. Café
  3. Tabaquismo
  4. Ejercicio
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4
Q

Clasificación de Kurman y Norris

A
  1. Hiperplasia simple (1%)
  2. Hiperplasia compleja (3%)
  3. Hiperplasia atípica simple (8%)
  4. Hiperplasia atípica compleja (29%)
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5
Q

Cuadro clínico

A

SUA
Jóvenes -> anovulación
Postmenopáusicas

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6
Q

Células en citología cervical

A

Glandulares atípicas

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7
Q

Métodos diagnósticos

A
  1. Cuadro clínico
  2. USG transvaginal
  3. Biopsia endometrial
  4. Histeroscopia
  5. Histerosonografía
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8
Q

Dx diferencial, clasificación

A

Benignas, iatrogénicas, enfermedades sistémicas, malignas

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9
Q

Dx diferenciales benignos

A

Polipos, adenomiosis, miomas uterinos

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10
Q

Iatrogénicas

A

Anticoagulantes, esteroides, quimioterapia, anticoncepción hormonal

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11
Q

Enfermedades sistémicas

A

Trastornos de la coagulación, hipotiroidismo, enfermedad renal o hepática. Enf. de Von Willebrand.

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12
Q

Malignas

A

Cáncer cervicouterino

Cáncer de endometrio

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13
Q

Indicaciones biopsia de endometrio

A

<45 años, SUA

Postmenopáusicas, SUA, endometrio >4 mm.

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14
Q

Aparato usado para biopsia de endometrio

A

Canula de pipelle

Novak

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15
Q

Diagnósticos con histeroscopia

A

Pólipos, miomas submucosos, otras lesiones

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16
Q

Tx

A

Progestinas

17
Q

Estándar de oro

A

Biopsia endometrial

18
Q

Tiempo medio de regresión

A

9 meses