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Pathology > High-Yield Pathology, USMLE > Flashcards

High-Yield Pathology, USMLE Flashcards

1
Q

Associated Neoplasm: Down Syndrome

A

ALL, AML

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2
Q

Associated Neoplasm: Xeroderma pegmetosum, albinism

A

Melanoma, basal cell carcinoma, and especially squamous cell carcinoma

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3
Q

Associated Neoplasm: Chronic atrophic gastritis, pernicious anemia

A

Gastric Adenocarcinoma

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4
Q

Associated Neoplasm: Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)

A

Astrocytoma, Angiomyolipoma, and cardiac rhabdomyoma

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5
Q

Associated Neoplasm: Actinic keratosis

A

Squamous Cell Carcinoma of skin

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6
Q

Associated Neoplasm: Barrett’s Esophagus

A

Esophageal Adenocarcinoma

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7
Q

Associated Neoplasm: Plummer-Vinson Syndrome (atrophic glossitis, esophageal webs, anemia all due to Fe def)

A

Squamous Cell Carcinoma of esophagus

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8
Q

Associated Neoplasm: Cirrhosis

A

Hepatocellular Carcinoma

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9
Q

Associated Neoplasm: Ulcerative Colitis

A

Colonic Adenocarcinoma

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10
Q

Associated Neoplasm: Paget’s disease of the bone

A

Secondary osteosarcoma

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11
Q

Associated Neoplasm: Immunodeficiency States

A

Malignant Lymphomas

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12
Q

Associated Neoplasm: AIDS

A

Aggressive Malignant Lymphoma

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13
Q

Associated Neoplasm: Autoimmune disease

A

Benign and Malignant Lymphomas

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14
Q

Associated Neoplasm: Acanthosis Nigricans

A

Visceral Malignancy

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15
Q

Associated Neoplasm: Dysplastic Nevus

A

Malignant Melanoma

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16
Q

Associated Neoplasm: Radiation Exposure

A

Sarcoma

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17
Q

Associated Tumor: abl

Oncogene or Tumor suppressor?

A

CML

Oncogene

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18
Q

Associated Tumor: c-myc

Oncogene or Tumor suppressor?

A

Burkitt’s lymphoma

Oncogene

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19
Q

Associated Tumor: bcl-2

Oncogene or Tumor suppressor?

A

Follicular and undifferentiated lymphoma

Oncogene

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20
Q

Associated Tumor: erb-B2

Oncogene or Tumor suppressor?

A

Breast, ovarian, and gastric carcinoma

Oncogene

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21
Q

Associated Tumor: ras

Oncogene or Tumor suppressor?

A

colon carcinoma

Oncogene

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22
Q

Associated Tumor: L-myc

Oncogene or Tumor suppressor?

A

Lung Cancer

Oncogene

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23
Q

Associated Tumor: N-myc

Oncogene or Tumor suppressor?

A

Neuroblastoma

Oncogene

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24
Q

Associated Tumor: ret

Oncogene or Tumor suppressor?

A

MEN II and III

Oncogene

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25
Associated Tumor: c-kit | Oncogene or Tumor suppressor?
Gastrointestinal stromal tumor | Oncogene
26
Associated Tumor: Rb | Oncogene or Tumor Suppressor
Retinoblastoma, Osteosarcoma | Tumor Suppressor
27
Associated Tumor: BRCA1 | Oncogene or Tumor Suppressor
Breast and Ovarian Cancer | Tumor Suppressor
28
Associated Tumor: BRCA2 | Oncogene or Tumor Suppressor
Breast | Tumor Suppressor
29
Associated Tumor: p53 | Oncogene or Tumor Suppressor
Most cancers | Tumor Suppressor
30
Associated Tumor: p16 | Oncogene or Tumor Suppressor
Melonoma | Tumor Suppressor
31
Associated Tumor: APC | Oncogene or Tumor Suppressor
``` Colorectal Cancer (FAP) Tumor Suppressor ```
32
Associated Tumor: WT1 | Oncogene or Tumor Suppressor
Wilm's Tumor | Tumor Suppressor
33
Associated Tumor: NF1 | Oncogene or Tumor Suppressor
Neurofibromatosis Type 1 | Tumor Suppressor
34
Associated Tumor: NF2 | Oncogene or Tumor Suppressor
Neurofibromatosis Type 2 | Tumor Suppressor
35
Associated Tumor: DPC | Oncogene or Tumor Suppressor
Pancreatic Cancer | Tumor Suppressor
36
Associated Tumor: DCC | Oncogene or Tumor Suppressor
Colon Cancer | Tumor Suppressor
37
Name the Neoplasm: Patient with Cushing's syndrome
ACTH - Small Cell Lung Cancer
38
Name the Neoplasm: Patient with SIADH
ADH - Small Cell Lung Cancer and Intracranial neoplasms
39
Name the Neoplasm: Patient with Hypercalcemia
PTH - Squamous Cell Lung Carcinoma, renal cell carcinoma, and Breast Cancer
40
Name the Neoplasm: Patient with Polycethemia
EPO - Renal Cell Carcinoma, hemangioblastoma
41
Name the Neoplasm: Patient with Lambert-Eaton Syndrome (progressive weakness w/out facial involvement)
Antibodies against presynaptic Ca2+ channels and NMJ - Thymoma, Small Cell Lung Cancer
42
Name the Neoplasm: Patient with Gout and/or urate nephropathy
Excessive Nucleic Acids - Leukemias and lymphomas
43
Psammoma bodies are found in these 4 cancers:
1. Papillary adenocarcinoma of the thyroid 2. Serous papillary cystadenocarcinoma of ovary 3. Meningioma 4. Malignant mesothelioma
44
Associated pathology(s): PSA
Prostate-specific antigen 1) Prostate CA 2) BPH 3) Prostatitis
45
Associated pathology(s): Prostatic acid phosphatase
Prostate carcinoma
46
Associated pathology(s): CEA
Carcinoembryonic antigen - very nonspecific. + in ~70% of colorectal and pancreatic cancers. Also in breast and gastric tumors
47
Associated pathology(s): a-Fetoprotein
NTDs Hepatocellular carcinoma Nonseminomatous germ cell tumor (yolk sac tumor) DECREASED in Downs Syndrome
48
Associated pathology(s): BhCG
Hydatidiform moles Choriocarcinomas Gestational trophoblastic tumors
49
Associated pathology(s): CA-125
Ovarian Cancer | Malignant epithelial tumors
50
Associated pathology(s): S-100
Melanoma Neural tumors Astrocytoma
51
Associated pathology(s): Alkaline phosphatase
Bone Metastases Obstructive biliary Disease Paget's disease
52
Associated pathology(s): Bombesin
Neuroblastoma | Lung and Gastric Cancer
53
Associated pathology(s): TRAP
Tartrate-resistant acid phophatase. | Hairy cell leukemia
54
Associated pathology(s): CA-19-9
Pancreatic adenocarcinoma
55
Affected Enzyme in Pb poisoning
Ferrochelatase and ALA dehydratase
56
Affected Enzyme in acute intermittent porphyria
Uroporphyrinogen I Synthase
57
Affected Enzyme in Porphyria cutanea tarda
Uroporphyrinogen decarboxylase
58
Accumulated substrate in Pb poisoning
Coproporphyrin and ALA
59
Accumulated substrate in acute intermittent porphyria
Porphobilinogen and delta-ALA
60
Accumulated substrate in Porphyria cutanea tarda
Uropophyrin
61
t(9,22)
Philadelphia chromsome - CML (bcr-abl hybrid)
62
t(8,14)
Burkitt's lymphoma (c-myc)
63
t(14,18)
Follicular lymphomas (bcl-2)
64
t(15,17)
M3 type of AML (responsive to all-trans retinoic acid)
65
t(11,22)
Ewing's sarcoma
66
t(11,14)
Mantle cell lymphoma
67
t(8,21)
M2 of AML

Pathology (16 decks)

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