High Yield

Question 1

Fibrin

Answer 1

Links Gp2b/3a to form PLT plug

Question 2

Thrombin functions

Answer 2

1. Fibrinogen to fibrin
2. Activates f5, 8
3. Activates PLTS

Question 3

AT3 Functions

Answer 3

1. Inhibits thrombin

2. Inhibits f9, 10, 11

Question 4

Plasmin

Answer 4

Degrades f5, 8, fibrinogen, and fibrin

Question 5

TXA2

Answer 5

Released from PLT
Ca release exposes Gp2b/3a
Increases PLT aggregation and promotes constriction

Question 6

Cryo

Answer 6

vWF, f8, fibrinogen

Question 7

FFP

Answer 7

All factors, Protein C and S, AT3

Question 8

DDAVP

Answer 8

Cause endothelium to release f8 and vWF

Question 9

Clopidogrel

Answer 9

MOA: ADP receptor (gp2b/3a) antagonist

Question 10

Aminocaproic acid

Answer 10

Plasmin inhibitor

Use: DIC, excess tpa

Question 11

Warfarin reversal

Answer 11

1. Emergent: PCC or f7a (more s/e)

2. Oral K

Question 12

Anti-staph Penicillins

Answer 12

Oxacillin
Methicillin
Nafcillin

Question 13

Beta lactamase inhibitors

Answer 13

Sulbactam
Clavulanic acid
Tazobactam

Question 14

Effective for enteroccous

Answer 14

Ampicillin
Amoxacillin
Vancomycin
Timentin
Zosyn
***resistant to all cephalosporins

Question 15

Effective for P/A/S

Answer 15

Ticarcillin, Piperacillin, Timentin
Zosyn
3G cephalosporin
Aminoglycodies (genta, tobra)
Meropenem, Imipenem
Flouroquinolones

Question 16

Effective for VRE

Answer 16

Synercid

LInezolid

Question 17

P450 inducers

Answer 17

Cruciform vegetables
ETOH
Cigarette smoke
Phenobarb
Barbiturates
Dilantin
Theophylline
Warfarin

Question 18

P450 inhibitors

Answer 18

Cimetidine
Isoniazid
Ketoconazole
Erythromycin
Cipro
Flagyl
Allopurinol
Verapamil
Amiodarons
MAOi
Disulfuram

Question 19

Halothane

Answer 19

Slow onset/offset. Least pungent (children)
s/e:
- highest cards depression and arrhythmia
- halothane hepatitis
- avoid w/ neurosurg

Question 20

Sevoflurane

Answer 20

fast, less laryngospasm, less pungent

good for mask induction

Question 21

Isoflurane

Answer 21

Good for neurosurgery

Pungent (not used for induction)

Question 22

Propofol

Answer 22

Rapid distribution and on/off
s/e- hypotension, resp depression, meta acid
metabolism- liver

Question 23

Ketamine

Answer 23

No respiratory depression
s/e
- hallucination, catelcholamine release, airway secretions, increased CBF
- c/i in head injury

Question 24

Etomidate

Answer 24

Fewer hemodynamic changes
Fast acting
Fewest cards s/e
s/e
- adrenocortical suppresion w/ cont infusion

Question 25

Dexmedetomidine

Answer 25

Mech- CNS alpha2 ago
Not an induction agent. Good for intubated pts
Anesthesia and analgesia
s/e
- not for more than 24h

Question 26

Depolarizing agents

Answer 26

Succinyl choice
Malignant hyperthermia
Hyperkalemia
Glaucoma

Question 27

Ca EKG

Answer 27

HyperCA- Short ST, wide T

HypoCA- long QT

Question 28

HypoMg EKG

Answer 28

Tall t waves

Depressed ST

Question 29

K ECG

Answer 29

HyperK- Peaked T, wide QRS, long PR

HypoK - ST depression, inverted T