Herpes & HPV

Question 1

cytomegalovirus (CMV) is a protypical member of

Answer 1

betaherpesvirus

Question 2

this herpes type is characterized by variable host range, short replication cycle, rapid culture spread, efficient cell destruction, sensory ganglia latency

Answer 2

alphaherpesvirus

Question 3

this herpes type is characterized by restricted host range, long replication cycle, slow growth in culture, CYTOMEGLIA, latency in a variety of tissues

Answer 3

betaherpesvirus

Question 4

Epstein-Barr virus (EBV) is a prototypical member of

Answer 4

gammaherpesvirus

Question 5

this herpes type targets T & B lymphocytes, causes lytic infections, restricted host range, lymphoid tissue latency

Answer 5

gammaherpesvirus

Question 6

Burkett’s lymphoma

Answer 6

EBV (gammaherpesvirus) associated carcinoma

Question 7

Hodgkin’s lymphoma

Answer 7

EBV present in majority of tumors

Question 8

which herpes virus does not have an innate antiviral host response

Answer 8

EBV

Question 9

persist in hematopoietic progenitor cells and macrophages in vitro ; common persistent infection (not latency)

Answer 9

CMV

Question 10

persistence of genome in memory B cells ; virus proteins ensure B cell proliferation and ___ genome replication

Answer 10

EBV

Question 11

Role of antiviral therapy

Answer 11

inhibit viral genome replication

Question 12

T/F? antiviral therapy ideal treatment for EBV induced lymphoproliferation

Answer 12

false

Question 13

why is antiviral therapy not effective for EBV induced lymphoproliferation

Answer 13

act to inhibit viral genome replication but genome replication not essential for viral genome expression

Question 14

genome for all herpes viruses and HPV

Answer 14

dsDNA

Question 15

virion type for all herpesvirus

Answer 15

enveloped

Question 16

virion type for HPV

Answer 16

non-enveloped

Question 17

HPV proteins

Answer 17

L1 - cell attachment

L2 - membrane protection

Question 18

how does HPV gain access?

Answer 18

abrasion of the skin

Question 19

where does HPV establish infection ?

Answer 19

basal layer

Question 20

required for HPV genome replication

Answer 20

cell polymerase

Question 21

HPV releases a (lytic/non lytic) virus?

Answer 21

non lytic

Question 22

HPV infection caused by

Answer 22

direct skin-skin contact - abrasions
fomites
mucous membranes more susceptible

Question 23

rare complication of HPV

Answer 23

respiratory papillomatosis

Question 24

HPV oncogenesis

Answer 24

cervical cancer
virus replication requires actively replicating cells
block tumor suppressor pathway and retinoblastoma protein for continued cell proliferation

Question 25

antiviral therapy

Answer 25

block specific steps in virus life cycle must be active against replication but not cell function to reduce toxicity resistance common

Question 26

antivirals preventing entry

Answer 26

enfuvirtide (HIV) | amantadine & rimantadine (influenza)

Question 27

antivirals preventing genome replication

Answer 27

``` nucleoside analogs acyclovir, gancyclovir, valgancyclovir Ribavirin Foscarnet Nucleoside inhibitors of HIV & HBV ```

Question 28

why is gancyclovir more toxic?

Answer 28

effective against CMV but interferes with cellular kinase

Question 29

antivirals preventing viral proteases

Answer 29

ritonavir

Question 30

foscarnet MOA

Answer 30

herpesvirus prevents viral polymerase activity IV admin, toxic

Question 31

ribavirin MOA

Answer 31

nucleoside inhibitor of RNA viruses inhibits polymerase or lower GTP in cell impairs mRNA capping

Question 32

ritonavir MOA

Answer 32

blocks virus polypeptide cleaving | boosts activity of other protease inhibitors

Question 33

maturation of progeny viruses often requires

Answer 33

cleavage of viral polypeptide

Question 34

acyclovir specificity depends on

Answer 34

virus thymadine kinase (TK)

Question 35

antiviral challenges

Answer 35

bioavailability specificity toxicity

Question 36

natural antivirals

Answer 36

interferons more effective against RNA viruses one cell affected transmits resistance

Question 37

practice of introducing immunity to a pathogen

Answer 37

vaccination

Question 38

administration of a pathogenic agent to induce antibodies or cell-mediated immunity

Answer 38

active immunization

Question 39

administration of exogenously produced antibodies

Answer 39

passive immunization

Question 40

what type of polio vaccine is used in the us?

Answer 40

killed because polio rate in the US is so low

Question 41

important immune cell types in vaccines

Answer 41

B cells CD8 T cells CD4 T cells

Question 42

B cell only vaccines

Answer 42

pneumonococcal | HIB

Question 43

B and T cell vaccines

Answer 43

influenza polio oral typhoid