Hepatitis

Question 1

hepatitis viruses mainly infect and replicate where?

Answer 1

hepatocytes

Question 2

liver damage in hepatitis is result of

Answer 2

virus and host response

Question 3

T/F? Hepatitis causes only acute infections

Answer 3

Can cause acute or chronic infections

Question 4

What are the types of hepatitis viruses?

Answer 4

Hep A
Hep B
Hep C
Hep delta (rare in US)
Hep E (rare in US)

Question 5

T/F? All 5 types are able to be transmitted sexually and parenterally

Answer 5

True

Question 6

Which hepatitis viruses are characterized by a non-enveloped virion?

Answer 6

Hep A & E

Question 7

Which hepatitis viruses are characterized by (+)ssRNA genome?

Answer 7

Hep A, C, E

Question 8

This virus has smallest genome of human viruses

Answer 8

Hep B - dsDNA

Question 9

Hepadnaviridae

Answer 9

Hep B

Question 10

T/F? Can easily grow hep B in cell culture

Answer 10

False, cannot nbe grown

Question 11

T/F? Hep B genome has RNA intermediate

Answer 11

True

Question 12

template for transcription in Hep B

Answer 12

cccDNA

Question 13

What is required for Hep B replication

Answer 13

liver specific transcription factors

Question 14

Contraction of Hep B

Answer 14

sex & drugs

Question 15

Hep B incubation period

Answer 15

30-180 days

Question 16

Symptoms of Hep B

Answer 16

general malaise, anorexia, vomiting, cough, serum-like sickness

jaundice, elevated ALT

Question 17

How do you confirm chronic Hep B infection?

Answer 17

Presence of HBsAg in blood for > 6 months
poor IgG response

very small 5% have chronic infection

Question 18

HBsAg

Answer 18

empty particles produced by hep virus
present in infected people
indicator of chronic disease

Question 19

Complications of Hep B

Answer 19

sporadic hepatitis
liver cirrhosis
increased risk for hepatocellular carcinoma (HCC)

Question 20

Hep B prevention & treatment

Answer 20

vaccine

treatment:
interferon-a therapy
nucleoside analogs

Question 21

This virus requires active HBV infection

Answer 21

Hep D

Question 22

Hep D Virus characteristics

Answer 22

subviral agent (rare in human viruses)
requires Hep B infection
RNA genome encodes a single protein

Question 23

T/F? RNA genome of Hep D encodes hundreds of proteins

Answer 23

False, encodes a single protein

Question 24

Flaviviridae

Answer 24

Hep C

Question 25

Hep C replication

Answer 25

genome passed into cytoplasm
genome template for translation
Ribosomes recognize internal ribosome entry sites (IRES)

Question 26

Hep C characteristics

Answer 26

milder s/s
mainly chronic infection
extrahepatic disease

Question 27

extrahepatic diseases associated with Hep C

Answer 27

Mixed cryoglobulinemia - antibody and virus complexes deposit in other tissues = immune response and tissue damage

Question 28

Hep C prevention and treatment

Answer 28

no vaccine

interferon-a treatment reduce chance of chronic infection

Question 29

Hep A contraction

Answer 29

ingestion of fecally contaminated food or water

absorbed thru intestine but moves to liver via portal system

Question 30

Hep A incubation

Answer 30

12-40 days

Question 31

Hep A prevention

Answer 31

vaccine

Question 32

Hep E characteristics

Answer 32

causes foodborne and waterborne hepatitis
similar to HAV, distinguished by serology
life threatening to pregnant women
no prevention

Question 33

Fecal-oral transmission but no vertical transmission

Answer 33

HAV , HEV

Question 34

Picornaviridae

Answer 34

Hep A

Question 35

Deltaviridae

Answer 35

Hep D

Question 36

Calciviridae

Answer 36

Hep E