Retroviruses

Question 1

retrovirus theory

Answer 1

SIV > HIV2 > HIV 1

Question 2

T/F? Retroviruses are ubiquitous in vertebrates

Answer 2

true

Question 3

_________ make foamy structures inside the cell

Answer 3

Spumaviruses

Question 4

T/F? Spumaviruses are most common cause of human disease

Answer 4

false ; do not cause human disease

Question 5

How do we classify retrovirus as simple or complex?

Answer 5

Based on its genome contents

Question 6

Simple retroviruses only encode what 4 genes?

Answer 6

Gag, Pro, Pol, Env

Question 7

Defining feature of retroviruses

Answer 7

reverse transcription ; necessary for infection to progress

Question 8

when is reverse transcription initiated?

Answer 8

once nucleocapsid is in cytoplasm

Question 9

T/F? High levels of NTP prevent reverse transcription from occurring

Answer 9

False; low levels prevent it, high levels are needed for it to occur

Question 10

Lentivirus

Answer 10

HIV

Question 11

Deltaretrovirus

Answer 11

HTLV

Question 12

for retrovirus integration, when does virus access nucleus?

Answer 12

during mitosis

Question 13

slow retroviruses

Answer 13

result in tumor formation

high level mutagenesis

Question 14

cytopathic retroviruses

Answer 14

direct tissue damage

Question 15

acute transforming viruses

Answer 15

cause rapid tumor formation

carry host gene

Question 16

primary mode of spread for HTLV-1 within host

Answer 16

contact between infected and naive cell

Question 17

HTLV-1 infects what cells?

Answer 17

memory CD4 T cells

Question 18

bladder control, ED, weak legs

Answer 18

HAM/TSP associated with HTLV-1

Question 19

HTLV-1 causes what illnesses?

Answer 19

HAM/TSP

ATLL

Question 20

HAM/TSP treatment

Answer 20

corticosteroids

Question 21

HIV targets what cells

Answer 21

CD4+ memory T cells

Question 22

what signs are indicative of HIV infection?

Answer 22

mucocutaneous ulceration

weight loss

Question 23

Nucleoside Reverse Transcriptase Inhibitor

Answer 23

AZT

Question 24

Non-nucleoside reverse transcriptase inhibitor

Answer 24

Efavirenz

Question 25

Protease inhibitor

Answer 25

Ritonavir

Question 26

retrovirus virion

Answer 26

enveloped

Question 27

retrovirus genome

Answer 27

diploid (+)ssRNA