Herpes Group Viruses (DNA) Enveloped, ds linear DNA

Question 1

Herpes simplex

Answer 1

Tzank smear test (multi-nucleated giant cells)

“HSV1: Temporal lobe Encephalitis (treat with IV acyclovir), Oral & some genital lesions, keratoconjunctivitis.
HSV2: Genital herpes, neonatal herpes, latant in sacral ganglia”

Question 2

Varicella zoster

Answer 2

Tzank smear test (multi-nucleated giant cells)

“Chickenpox - Shingles, encephalitis, pneumonia, latent in dorsal root (trigeminal) ganglia.
Transmission: respiratory secretions”

Question 3

Cytomegalovirus (CMV)

Answer 3

Infected cells have characteristic Owl’s eye inclusion.

Pizza eye. Congenital infection. Heterophile mononucleosis (negative monospot test). Directly related to CD4 count. Pneumonia. Retinitis.

Question 4

Epstein-Barr virus

Answer 4

Latent in B-lymphocytes.

Infectious mononucleosis. Burkitt’s/Hodgkin’s lymphoma. Nasopharyngeocarcinoma. Monospot test

Question 5

Human herpesvirus type 6

Answer 5

Roseola. High fever, then seizure, then rash: Trunk-to-face

Question 6

HHV type 8

Answer 6

LANA (latency-associated nuclear antigen) –> Kaposi’s sarcoma, caused by sexual contact.