Enteroviruses:

Question 1

Poliovirus (Picorna)

Answer 1

“Envelope: No
RNA Structure: SS + linear
Capsid Symmetry: Icosahedral
Genome is infectious”

"Vaccination – live vs. killed
Salk: killed (IgG)
Sabin: live (IgG, IgA) 
IPV/OPV
Aseptic meningitis"

Question 2

Coxsackie virus (Picorna)

Answer 2

“A= herpangina, hand foot mouth disease. B=myocarditis

Both: aseptic meningitis, URI”

Question 3

Echovirus (Picorna)

Answer 3

Aseptic meningitis: 10 days, gets better

Question 4

Rhinovirus (Picorna)

Answer 4

“colds
binds to ICAM-1
Acid-labile: destroyed by stomach acid and doesn’t afect GI tract (unlike other picornaviruses)
Replicates best at 33C”

Question 5

Hepatitis A (Picorna)

Answer 5

“Enterovirus
Fecal-oral transmission
short incubation

“Fecal-oral. Raw oysters
Asmptomatic, Acute, Alone (no carriers)
No HCC risk”

Question 6

Norwalk (Calciviridae)

Answer 6

"Envelope: No
RNA Structure: SS + linear  
Capsid Symmetry:  Icosahedral
"
No vaccine. Diarrhea – common source outbreak.

Question 7

Hepatitis E (Calciviridae)

Answer 7

” Fecal-oral transmission, esp. with waterborn epidemics
Short incubation

“High mortality in pregnant women: Enteric, Expectant mothers, Epidemic
Norovirus: 24 hour nausea, vomiting, diarrhea
Gastroenteritis
No HCC risk”

Question 8

Rotavirus (Reoviridae)

Answer 8

“Envelope: No
RNA Structure: DS linear, 10-12 segments
Capsid Symmetry: Icosahedral (double)
Semgemted dsRNA
Villous destruction with atrophy leads to less absorption of Na+ and K+

“Watery diarrhea
Most important global cause of infantile gastroenteritis
Major cause of acute diarrhea in U.S. during winter
ROTAvirus = Right Out The Anus”

Question 9

Prion diseases

Answer 9

“CNS plaques. Creutzfeld-Jacob: tremors, ataxia in CJD.

General: Tremors, ataxia “