CSV Flashcards
1
Q
- Characteristics
A
- mediated - IgE
2
Q
- Characteristics
A
- mediated - Ab-mediated cytotoxicity; Ab attack tissue
3
Q
- Characteristics
A
- mediated - immune complex deposition
4
Q
- Characteristics
A
- mediated - cell mediated (TH cells)
5
Q
- All others
A
- B27
6
Q
- Mechanism
A
- MG
7
Q
- Associated
A
- Wegner’s granulomatosis
8
Q
- Mechanism
A
- Goodpasture’s syndrome
9
Q
- Mechanism
A
- Dx - MS
10
Q
Immunlogic features to DM1
A
- anti-islet cell Ab
11
Q
- type of hypersensitivity
A
- Mechanism - Rheumatoid factor (IgM Ab to own IgG)
12
Q
- mechanism
A
- Scleroderma
13
Q
CREST
A
C calcinosis
14
Q
- anti-Jo-1
A
- anti-DNA, anti-Sm - lupus
15
Q
- clinical example
A
- defect (component) - T cells
16
Q
- clinical example
A
- defect (component) - B cells
17
Q
- clinical example
A
- defect (component) - B cells
18
Q
- clinical example
A
- defect (component) - phagocytes
19
Q
- clinical example
A
- defect (component) - complement
20
Q
- Characteristics
A
- Dx - chronic granulomatous dis
21
Q
- Characteristics
A
- Dx - leukocyte adhesion def (LAD)
22
Q
- Characteristics
A
- Dx - Chediak-Higashi dis
23
Q
- Characteristics
A
- Dx - X-linked (Bruton’s) agammaglobulinemia
24
Q
- Characteristics
A
- Dx - selective IgA deficiency
25
2. Characteristics
1. Dx - common variable immunideficiency
26
2. Characteristics
1. Dx - SCID
27
2. Characteristics
1. Dx - Herediatary atxia-telangiectasia
28
2. Characteristics
1. Dx - Wiskott- Aldrich
29
2. Characteristics
1. Dx - Chronic mucocutaneous candidiasis
30
2. Characteristics
1. Dx - DiGeorge (congenital thymic aplasia)
31
5. DAF, HRF, or CD59
1. C1qrs, C2, or C4 - immune complex dis
32
4. complement defects asoc w/
1. humoral defects (b cells) assoc w/ - common infections (otitis mdia, sinusitis)
33
In transplant,HLA match
HLA match - A, B, and DR
34
3. fxn
1. source - TH1 cells and NK cells
35
3. fxn
1. source - TH1
36
3. fxn
1. source - APCs (macrophages)
37
3. fxn
1. source - Macrophages
38
3. fxn
1. source - TH2
39
3. fxn
1. source - Th2
40
3. fxn
1. source - Th2
41
4. Activate:
1. Differentiate by: IL-1, 12, and IFN-gamma (from Macro)
42
3. Inhibited by:
1. differentiate by: IL-4 (from mast cells and eosinophils)
43
Thymus secretes what to differentiate lymphocytes into T cells?
thymopoietins I and II
44
2. medulla
1. Cortex - express CD3 and both CD4 and 8 and aquire TCRs
45
What activates effectr T cells in periphery
macrophages
46
2. Cytokine response
1. CD28 - binds CD80/CD86 on APC
47
2. cytokine response
1. CD28 binds CD80/86 o APC
48
If CD28 on T cells is downregulated ...
CTLA-4 is upregulated and T cell is inactvated
49
Papain vs Pepsin
Papain - cleaves Ig at the hinge region
50
IgM
pentamer (j chain)
51
IgG
high affinity
52
IgE
hig affinity FcE receptors on mst cells and basophils
53
IgA
found in secretions and mucus
54
IgD
primarily xpr on B cell surface
55
Complement is synthesized by
hepatocytes (in the liver)
56
3. Lectin
1. classic - Ab mediated
57
1. Players
1. C1, 4, 2, 3, 5-9 and Ab on surface of microbe
58
1. players
Mannan-binding lectin binds bacterial carbs and activates C4, 2, 3, 5-9
59
2. 6 steps
1. activated by: LPS, IgA aggregates, and Cobra venom
60
3. C5a
1. C3a - inflammation
61
What are C3a, C4a, and C5a?
Anaphylatoxins - recrut phagocytes, promote inflammation, chemokines, and vasodilation
62
2. mechanism
1. evasion tactic - resistance to phagocytosis
63
2. mechanism
1. evasion tactic - resistance to phagocytosis
64
2. mechanism
1. evasion tactic - resistance ROS
65
2. mechanism
1. evasion tactic - resistance to complement
66
2. mechanism
1. evasion tactic - resistance to complement
67
2. fxn
1. liver in response to IL-6
68
2. associated with
1. IFN-a - leukocytes
69
2. associated with
1. IFN-g made by NK, CD4 Th1 and CD8 T cells
70
2. Decrease
1. ribonucleases, prteases, (prevent replication); MHC I xpr (promote recog) and cytotoxic actions of NK cells
71
1. increase
1. phagocytic andmicrobial capabilities of macroph.
72
2. Decrease
Cell walls of bacteria that contain endotowin (LPS)
73
Acute phase proteins
IL-1, IL-6 and TNF
74
IFN a and b have what kind of activity
antiviral
75
IL-5 activates
eosinophils
76
2 myeloid series need _
1. IL-7
77
Monocytes/macrophages are identified by what marker
CD14
78
NK cells activated by
IL-1, IL-2, IL-18 (esp!) and IFN-g
79
Innate immunity can recognize broad classes of microbial pathogens based on pathogen associated molecular patterns (PAMPs) - 4 examples
LPS/endotoxin
80
TLR 9
TLR 1 - triacyl lipoproteins
81
2. pathway for each
1. superoxide, hypochlorite, hydroxyl radical
