Hepatology

Question 1

Aspartate transaminase (AST)

Answer 1

0-50 IU/L

Elevated during acute liver injury

NOT A TRUE MARKER OF LIVER FUNCTION

Question 2

Alanine transaminase (ALT)

Answer 2

0-50 IU/L

Elevated during acute liver injury

NOT A TRUE MARKER OF LIVER FUNCTION

Question 3

Alkaline phosphatase (Alk phos)

Answer 3

30-120 IU/L

Elevated during biliary tract injury (gallstone)

NOT A TRUE MARKER OF LIVER FUNCTION

Question 4

Bilirubin

Answer 4

Elevated during acute/chronic liver issues

Question 5

Albumin

Answer 5

Reduced during chronic liver disease

Question 6

INR

Answer 6

Elevated during chronic liver disease

Question 7

DILI

Answer 7

Incidence: 2/10,000 patients

Direct
Indirect
Idiosyncratic

Question 8

Acetaminophen DILI

Answer 8

Acute ingestion of high doses (> or equal to 8 g) resulting in toxic levels of NAPQI

Question 9

Acetaminophen overdose signs/symptoms

Answer 9

Abdominal pain

Jaundice

N/V/D

Question 10

Acetaminophen overdose monitoring

Answer 10

AST/ALT–> q12-24 hours

Signs/symptoms

Acetaminophen concentration

Question 11

Treatment for acetaminophen overdose

Answer 11

N-acetylcysteine +/- activated charcoal

Question 12

Other drugs that can cause DILI

Answer 12

Penicillin, cephalosporins
Macrolide
Fluoroquinolone
Isoniazid–>monitoring @ baseline