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PHRM 864 Exam 4 > Biologics: other > Flashcards

Biologics: other Flashcards

1
Q

natalizumab MOA

A

Anti-alpha-subunit of integrins

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2
Q

natalizumab indications

A

CD

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3
Q

natalizumab place in therapy

A

Inducing and maintaining remission

Used in pts who fail/don’t tolerate TNF inhibitors

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4
Q

natalizumab ADRs

A

Associated with PML

Hypersensitivity reactions

ADAs

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5
Q

natalizumab monitoring

A

JC antibody

Neurological events

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6
Q

natalizumab pearls

A

Do not use in combination with immunosuppressants, TNF inhibitors

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7
Q

vedolizumab MOA

A

Anti-a4b7 integrin antibody

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8
Q

vedolizumab indications

A

UC, CD

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9
Q

vedolizumab place in therapy

A

Inducing and maintaining remission

Decreasing steroid-dependence

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10
Q

vedolizumab ADRs

A

Hypersensitivity reactions

ADAs

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11
Q

vedolizumab monitoring

A

TDM possible

Close monitoring of PML

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PHRM 864 Exam 4 (22 decks)

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