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ECVECC Board Exam > Hepatobiliary > Flashcards

Hepatobiliary Flashcards

1
Q

What is the only plasma protein that is not formed by the liver?

A

gamma globulin

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2
Q

How is heme coverted into bilirubin?

A

Heme → biliverdin (in the mononuclear cells by heme oxygenase) → unconjugated bilirubin (lipophilic; by biliverdin reductase) → conjugated bilirubin (water soluble; via glucuronidation)

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3
Q

Iron metabolism in liver

A

Absorbed in GI –> ferroportin (regulated by hepcidin) –> transferrin –> hepatocite with apoferritin and hemosiderin

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4
Q

What are the two hormones that can activate phosphorylase and facilitate glycogenolysis?

A

Epinephrine
Glucagon

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5
Q

How many ATPs are produced during glycolysis, Krebs cycle and oxidative phosphorylation?

A

Glycolysis: 2
Krebs cycle: 2
Oxidative phosphorylation: 34

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6
Q

True or False: ATP provides negative feedback to inhibit the glycolysis.

A

True

ATP inhibit phosphofructokinase, which is the rate limiting enzyme

It covert

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7
Q

What does phosphofructokinase do?

A

It converts fructose-6-phosphate to fructose-1,6-bisphosphate.

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8
Q

True or False: Citrate ions from citric acid cycle provides negative feedback to inhibit the glycolysis.

A

True

Inhibit phosphofructokinase

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9
Q

Besides glycolysis, what is the pathway that is responsible for up to 30% of glucose breakdown in the liver and adipose tissue?

A

Pentose phosphate pathway

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10
Q

What are the three main types of lipids in the body?

A

Triglyceride (contains fatty acid)
Phospholipids (contains fatty acid)
Cholesterol (do not contain fatty acid)

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11
Q

How does body utilize fatty acid as source of energy?

A

fatty acids are converted to acetyl-CoA via 𝜷-oxidation → acetyl-CoA enters Krebs cycle → 22 ATP

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12
Q

List 3 hormones that facilitate lipolysis.

A

Thyroid hormone
Epinephrine
Cortisol

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13
Q

What is the normal ratio of body tissue protein and plasma protein?

A

33:1

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14
Q

For the liver bloody & oxygen supply, how many percentage are from the portal vein and how many percentage are from the hepatic artery?

A

Blood: 80% from portal vein, 20% from hepatic artery
Oxygen: 50% from portal vein, 50% from hepatic artery

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15
Q

What are the amino acid participating in the urea cycle?

A

Aspartate
Ornithine
Arginine
* Citrulline

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16
Q

What are the two hormones that facilitate protein synthesis? Which hormone facilitates protein breakdown?

A

Protein synthesis: insulin, growth hormone
Protein breakdown: glucocorticoid

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17
Q

What is the function of space of Disse?

A

allow excessive fluid from the liver sinusoid enter and drained from the lymphatic system

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18
Q

How many liver lobes are in dogs?

A

Four lobes with four sublobes and 2 processes

Right lateral, Right medial, Left lateral, Left medial, caudate, quadrate

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19
Q

What is the main difference in the bile duct anatomy in dogs and cats?

A

Dogs:
- Common bile duct enters the duodenum at the major duodenal papilla adjacent to the pancreatic duct (not conjoined)
- The accessory pancreatic duct (which is the main pancreatic enzymes secretion site) enters the duodenum a the minor duodenal papilla

Cats:
- The common bile duct and the pancreatic duct conjoin before enter the duodenum at the major duodenal papilla
- Only approximately 20% of cats have a smaller, accessory pancreatic duct that exits at a minor duodenal papilla

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20
Q

List 5 substances that is in the bile.

A

1) Bile acid
2) Cholesterol
3) Bilirubin
4) Phospholipids
5) Water
6) Bicarbonate

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21
Q

How many percentage of the liver removal can dogs tolerate?

A

70%
* The main issue is the liver being unable to accommodate the portal vein blood flow and develop portal hypertension

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22
Q

How soon does liver regeneration start and when is the peak?

A

starts within hours
Peak at 3 days

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23
Q

Which liver lobe is most likely to develop liver lobe torsion?

A

Left lateral

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24
Q

What are the two common concurrent endocrine disease with gallbladder mucocele?

A

Hyperadrenocorticism
Hypothyroidism

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25
Explain the enterohepatic circulation of bile acid.
**Cholesterol** enters the liver → breaks down to **unconjugated primary bile acid** → conjugates with glycine, taurine → **conjugated bile acid** and enters the gall bladder → enters the intestines at the level of duodenum → being actively absorbed at ileum (90%) / the rest 10% modified by bacteria (**secondary bile acids**) and enters the colon → the reabsorbed (95%) conjugated and unconjugated bile acids are efficiently extracted by hepatocyte transporters → only 5% remains in the systemic circulation for us to measure.
26
What is the reason of doing pre- and post-prandial bile acid test?
Providing food is a challenge to see if the liver can handle extra bile acid after the bile acid is secreted into the GI tract.
27
How do you interpret the bile acid test.
Bile acid concentrations >25-30 μmol/L in dogs and > 25 μmol/L in cats are suggestive of hepatobiliary disease. * whether pre- or post- is higher doesn't really matter Eclinpath
28
What are the three differential for abnormally high bile acid test?
Hepatic dysfunction Hepatic vascular anomaly Bile duct obstruction
29
What are the surgical options for PSS?
- Suture ligation - Gradual attenuation with ameroid constrictors - Gradual attenuation with cellophan bands
30
What is normal portal vein pressure?
6-10 mmHg
31
What are the clinical signs to observe after PSS surgery for portal hypertension?
Seizure Pain Intra-abdominal hypertension Hypovolemic shock Vomiting, diarrhea Distended abdomen with effusion
32
What are the two common causes for hepatic encephalopathy in dogs and cats, respectively?
Dog: CPSS, formation of acquired portosystemic collateral vessels (APSC) due to portal hypertension Cat: CPSS, arginine deficiency due to hepatic lipidosis
33
What is the classification of HE?
Type A: due to acute hepatic failure Type B: due to portal systemic bypass (e.g. CPSS) with normal hepatic function Type C: due to cirrhosis, PH or acquired portal systemic shunting - Episodic, persistent, minimal
34
What is the important enzyme to covert glutamine to ammonia and glutamate?
glutaminase (high level in enterocytes)
35
What are the two metabolic pathways for ammonia in the liver? what cells are responsible for that? what are their affinity and capacity?
1) Urea cycle, periportal hepatocytes, low affinity but high capacity 2) Glutamine synthesis, perivenous hepatocytes, high affinity but low capacity
36
What composes the portal triad?
Portal vein Hepatic artery Bile duct
37
which hepatic zone does acetaminophen most likely to cause injury?
zone 3
38
Which hepatic zone does gluconeogenesis happen? What about glycolysis?
Gluconeogenesis: zone 1 Glycolysis: zone 3 (anaerobic metabolism)
39
In a patient with liver disease, does the skeletal muscle help decrease ammonia level or elevate ammonia level?
Help to decrease ammonia level (contains glutamine synthase)
40
In the cerebrum, what is the interaction between astrocytes and ammonia?
Astrocytes have high level of glutamine synthase → metabolize ammonia → astrocyte swelling (?)
41
What are the 6 proposed pathogenesis of hepatic encephalopathy?
1) Astrocyte swelling (ammonia, cytotoxic and vasogenic edema) 2) Immuno-compromise and neuroinflammation 3) Oxydative stress 4) Manganese 5) Neurosteroid synthesis 6) Amino acid imbalance
42
True or False: Stimulation of peripheral type of benzodiazepine receptors (PTBR) by NH4 and manganese enhances synthesis of NS
True
43
List 4 rationales of using lactulose in treating hepatic encephalopathy.
1) Decrease colonic **pH** → trapping ammonium ions in the colon → decrease intestinal absorption (more NH4 form which is hydrophylic) 2) **probiotic** by inhibit ammonia producing bacteria 3) Reduce **intestinal transit time **→ decreased bacterial ammonia release/absorbtion and increase fecal excretion of nitrogen compounds 4) Stimulate the incorporation of ammonia with **bacterial proteins**
44
True or False: In the pathogenesis of hepatic encephalopathy, deranged GABAnergic neurotransmission plays a role.
True
45
What kind of amino acid imbalance is found to be associated with HE?
Increased aromatic amino acids and decreased branched-chain amino acids
46
List 10 possible precipitating factors for HE in dogs and cats?
1) High protein meal 2) GI bleeding 3) Arginine deficiency in cats 4) Hypokalemia 5) Alkalosis 6) Azotemia 7) Sedation uses 8) Blood transfusion 9) SIRS 10) diuretic administration
47
How does hypokalemia worsen hepatic encephalopathy
* **Increased Ammonia Production** Hypokalemia induces intracellular acidosis. To compensate for low potassium levels, the body shifts hydrogen ions (H⁺) into cells in exchange for potassium. This cellular acidosis leads to increased renal production of ammonia. Additionally, intracellular acidosis in the kidney's tubular cells promotes ammoniagenesis, leading to elevated blood ammonia levels. * **Increased Alkalosis (Metabolic)** Hypokalemia often accompanies metabolic alkalosis, which decreases blood hydrogen ion concentration. This alkalotic state shifts more ammonia (NH₃) into its diffusible, toxic form. In an alkalotic environment, ammonia is more likely to cross the blood-brain barrier and cause neurological disturbances, worsening hepatic encephalopathy. * **Impaired Hepatic Detoxification** Hypokalemia may impair hepatic function, particularly the liver’s ability to detoxify ammonia. The liver’s urea cycle, responsible for converting ammonia into urea for excretion, can become less efficient under hypokalemic conditions, leading to further increases in circulating ammonia levels. * **Worsened Neuromuscular and Neurological Symptoms** Hypokalemia can exacerbate muscle weakness and neurological disturbances (e.g., confusion, lethargy), both of which are already present in hepatic encephalopathy. This can compound the cognitive and neuromuscular dysfunction seen in HE.
48
True or False: In HE patients, strict protein-restricted diet is recommended.
False
49
What is the neomycin dose for HE?
20 mg/kg PO q8h
50
In dogs and cats, what are the two main types of cholecystitis?
Neutrophilic cholecystitis Lymphoplasmacytic follicular cholecystitis
51
What are the three types of necrotizing cholecystitis?
Type I: areas of necrosis without gallbladder rupture Type II: acute inflammation with rupture Type III: chronic inflammation with adhesions and/or fistulae to adjacent organs
52
How do you diagnosed bile peritonitis?
effusion bilirubin concentration > 2x serum bilirubin
53
what are the dogs and cats choleliths mainly composed of?
Calcium carbonate Bilirubin pigments (bilirubin or calcium bilirubinate)
54
What is the function of SAMe?
It is a glutathione precursor and antioxidant
55
Why is gall bladder mucocele a surgical disease.
The cause of gallbladder mucocele is thought to be a combination of increased mucin production & decrease GB motility. On histopathology exam, cystic mucinous hyperplasia is often found. If we just treat medically, mucocele can recur.
56
True or False: TNF-𝜶 stimulates hepatocyte apoptosis through the Fas-Fas ligand pathway.
True
57
List 10 hepatotoxin.
1) Carprofen 2) Acetaminophen 3) Xylitol 4) Alfatoxin 5) Sago palm 6) Phenobarbital 7) Aspirin 8) Amiodarone 9) Azole antifungals 10) Diazepam (oral) 11) Methimazole 12) Tetracycline 13) Blue-green algae
58
What the treatment difference in feline neutrophilic cholecystitis and lymphoplasmacytic cholecystitis?
Neutrophilic cholecystitis: broad-spectrum antibiotic while pending culture Lymphoplasmacytic cholecystitis: immunosuppressive glucocorticoid therapy
59
What is the main way for the body to maintain copper homeostasis?
Biliary excretion (→ any cause of cholestasis would be expected to increase hepatic copper level)
60
Describe the pathophysiology of hepatorenal syndrome.
Hepatorenal syndrome is a condition in which there is progressive kidney failure that occurs in a person with cirrhosis of the liver.
61
How much of the liver function loss can cause HE?
> 70%
62
What is the proposed pathophysiology of HE related seizure and coma/CNS depression?
Seizure: Excessive glutamate activates NMDA receptors Coma/CNS depression: Activations of GABA receptors and increased endogenous BZDs
63
List 10 toxin implicated in hepatic encephalopathy.
1) Ammonia - Increased brain tryptophan and glutamine 2) Endogenous benzodiazepam 3) Aromatic fatty acid - Decreased DOPA neurotransmitter synthesis 4) Maganeses 5) Tryptophan - direct neurotoxicity 6) Glutamine - Alters BBB amino acid transport 7) Bile acids 8) GABA 9) Short chain fatty acids (SCFA) 10) Decreased alpha-ketoglutaramate
64
What are the two proposed mechanism of PU/PD in acute liver injury/failure?
1) Decrease urea production → unable to establish the concentration gradient in renal medulla 2) Decrease responsiveness to ADH
65
What is the half life of albumin in dogs and cats?
8 days
66
What is half-life of ALT in dogs and cats?
Dogs: ~60 hours Cats: < 24 hours
67
True or False: Dog can synthesize conjugated bilirubin in their renal tubule.
True
68
What is the protein restriction for dogs and cats with liver failure?
Dog: 18-22% Cat: 30-35%
69
What is the MOA of ursodial
1) Cytoprotective effect: protect hepatocytes and cholangiocytes from bile acid-induced damage 2) Shift the concentration of bile acids from hydrophobicity to hydrophilicity (less toxic) 3) Induce the secretion of bile acids 4) Immunomodulating effect on hepatocytes
70
What are the 4 most common PSS post-OP complications?
Hemorrhage Hypoglycemia Seizure Portal hypertension
71
What change of the portal pressure is considered safe during PSS attenuation ?
< no greater than 10 cm of H2O
72
True or False: Carprofen induced liver toxicity is dose-dependent.
False It's idiosyncratic
73
What is the characteristic of hepatic lipidosis?
- Accumulation of **triglycerides** in more than **80% of the hepatocytes** - Intrahepatic **cholestasis** - Secondary impairment of hepatic functions IM text book said > 50%
74
Describe the proposed pathophysiology of hepatic lipidosis in cats.
Anorexia/Fasting & Stress → Negative energy balance → lipolysis → overwhelmed fatty acid oxidation → excessive fatty acids cumulate in the hepatocytes in the form of triglycerides (by esterification)
75
True or False: Insulin resistance is the major inciting factors for the development of feline hepatic lipidosis.
False
76
What are the three common electrolytes imbalances that are commonly seen in feline hepatic lipidosis?
Hypokalemia (poor prognostic indicator) Hypomagenesemia Hypophosphatemia
77
What is the recommended diet management for feline hepatic lipidosis?
High protein, low carb diet Protein (30-40% of the metabolized energy) Fat (50% of the metabolized energy) Carbohydrate (20% of the metabolized energy)
78
What is kernicterus?
Bilirubin encephalopathy (bilirubin > 20 mg/dL; mainly unconjugated)
79
What are the primary functions in hepatic zone 1 and hepatic zone 3, respectively?
Zone 1: glucuronidation, 𝜷- hydroxylation, urea synthesis Zone 3: lypolysis, glycolysis, gluconeogenesis, xenobiotic metabolism
80
Which hepatic zone has highest concentration of cytochrome p450?
Zone 3 which metabolizes xenobiotic chemicals and performs functions such as lipogenesis, glycolysis, bile acid synthesis and glutamine synthesis
81
Which hepatic zone has most hepatic progenitor cells and damage to this zone can affect liver's regeneration?
Zone 1
82
True or False: Acute liver injury cause hypophosphatemia.
True
83
What is hepatic metabolism phase1 and phase2?
Phase 1: cytochrome P450 - Oxidation, hydrolysis, reduction, dehalogenation Phase 2: conjugation pathway - Glucoronidation, sulfation, glutathine conjugation, acetylation, amino acid conjugation, methylation
84
Definition of acute liver failure vs acute liver injury
ALF = hepatocellular damage causeing acute compromise in synthetic, excretory and regulatory function of the liver ALI = acute hepatocellular damage with retained hepatic function
85
Mechanism of toxicity for: 1. Blue green algae 2. Amanita 3. Xylitol
1. disruption hepatocyte cytoskeleton 2. necrosis (can give penicillin to reduce protein binding) 3. depletion of ATP and production of ROS
86
TEG findings in ALF
50% hypocoagulable 10% hypercoagulable 40% no changes mainly increased LY and decreased MA
87
Best antibiotic for PSS
Rifaximin
88
Portal vein pressure
PVP = PBF x IHVR PBF = portal blood flow IHVR = intrahepatic venous resistance
89
Classification of portal hypertension
* Hepatic * pre-hepatic * post-hepatic (Budd-Chiari syndrome)
90
Measurement of PVP
* Direct catheterization * Indirect catheterization of CVC and hepatic vein: wedge pressure (= sinusoid pressure) vs free pressure (CVC) --> hepatic pressure gradient = wedge - free pressure --> if >10mmHg abnormal
91
Consequences of portal hypertension
* spontaneous bacterial peritonitis * hepato-renal syndrome * hypersplenism * portal hypertensive gastropathy
92
neurological complication after PSS surgery are more common in cats than in dogs
True: 20% vs 37%
93
Prognosis is better for intra-hepatic vs extra-hepatic shunts
False: 2.5-7% mortality in extra-hepatic vs 12.5% mortality in intra-hepatic
94
Treatment for copper hepatopathy
* Zinc (competitive transport in hepatocyte) * Trientine (chelates circulating copper) * D-penicillamine (chelates circulating and tissue copper but GI side effects and hemolytic anemia possible)
95
Lesion affecting the right hepatic lobe are easier to resolve by lobectomy than left sided ones
False: right lobes are more difficult to remove due to challenging access to lobar vasculature. Usually only partial lobectomy possible

ECVECC Board Exam (24 decks)

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