Hepato

Question 1

What is Tyzzer’s disease ? (etiology, target population, clinical signs)

Answer 1

Clostridium piliforme acute necrotising hepatitis = Tyzzer’s disease
Clostridium piliforme is a Gram-negative, obligate intracellular spore-forming manure- and soil-borne bacterium.
Hepatic lesions predominate in foals, with profound hypoglycaemia and variable increases in hepatic enzymes

Successful management of an outbreak of Tyzzer’s disease on a Thoroughbred breeding farm in central Kentucky; use of sorbitol dehydrogenase to identify sub-clinical cases
EVE 2023

Question 1

What is the ddx of hepatic failure in neonates ?

Answer 1

- EHV-1
- Tyzzer’s disease
- neonatal isoerythrolysis
- acute iron toxicity
- congenital biliary atresia
- hypoxic injury

Successful management of an outbreak of Tyzzer’s disease on a Thoroughbred breeding farm in central Kentucky; use of sorbitol dehydrogenase to identify sub-clinical cases
EVE 2023

Question 2

What biomarker could be used to identify subclinical or early-onset Tyzzer disease?

Answer 2

SDH (Sorbitol deshydrogenase) lacks specificity but might be the most sensitive test available during a Tyzzer’s disease outbreak.

Successful management of an outbreak of Tyzzer’s disease on a Thoroughbred breeding farm in central Kentucky; use of sorbitol dehydrogenase to identify sub-clinical cases
EVE 2023