Dermato Flashcards

1
Q

What is the best diagnostic method between fine needle aspiration and superficial swab to diagnose sarcoids? And why ?

A

PCR-based screening of FNA for BPV-1/− 2 represents a valid method to improve the consistency and quality of sarcoid diagnosis.
FNA is a rapid and easily performed procedure. It allows for BPV detection in both ulcerated and non-ulcerated sarcoids and concurrently prevents false positive results from superficial contamination.

Cross-sectional comparison of superficial swab and fine-needle aspiration:
Improving the diagnostic workup of horses with sarcoids
Vet. J 2022

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2
Q

What is the expected overall response rate using 4 doses of ALVAC-fIL2 for sarcoid treatment ?

A

Tumor size decreased in 86% of the horses, and the median time to first response was 89 days. Adverse events were minimal and included transient focal inflammation in 2 horses.

ALVAC-fIL2, a feline interleukin-2 immunomodulator,
as a treatment for sarcoids in horses: A pilot study
JVIM 2022

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3
Q

What is the efficacy of oral and subcutaneous administration of mistletoe extract for the treatment of equine sarcoids ?

A

No statistically significant difference in the effectiveness of systemic mistletoe extract (PO and SC) versus placebo against equine sarcoids

A randomized placebo-controlled double-blinded study
comparing oral and subcutaneous administration of mistletoe
extract for the treatment of equine sarcoid disease
JVIM 2024

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4
Q

Which histological feature is associated with lower recurrence of equine sarcoids following surgical removal ?

A

Superficial inflammation was significantly associated with reduced odds of recurrence of equine sarcoids at their original surgical removal site.
It is noteworthy that treatments for equine sarcoids, such as the topical chemotherapeutic agents 5-fluorouracil and imiquimod, probably work by inducing ulceration and active inflammation.

Histological evidence of superficial inflammation is associated with lower
recurrence of equine sarcoids following surgical removal: A follow-up study
of 106 tumours in 64 horses
Vet. J. 2023

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5
Q

What are the cutaneous diseases associated with BPV and EcPV ?

A

BPV-1, 2 and 13 : equine sarcoids
Equus caballus PV-1 : oral warts of young horses
EcPV-2 : genital papillomas
EcPV-1 to 9 : aural plague
Equus asinus PV-1 to 3 : disease ?

Novel equid papillomavirus from domestic donkey
evj 2024

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6
Q

What is the safety and efficacy of strontium plesiotherapy for the treatment of equine sarcoids ?

A

Strontium plesiotherapy appears to be an effective and safe method of treating selected sarcoids (complete resolution in all 10 cases).
Longer term follow-up is required to determine the risk of recurrence of treated lesions.

Strontium plesiotherapy for the treatment of sarcoids in the horse
eve 2020

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7
Q

Which are the BPV associated with equine sarcoids ?

A

BPV-1, BPV-2, and BPV-13 (recently isolated in Brazil, but not in Austria)

Screening for bovine papillomavirus type 13 (BPV13) in a
European population of sarcoid-­ bearing equids
EVJ 2022

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