Dermato Flashcards
What is the best diagnostic method between fine needle aspiration and superficial swab to diagnose sarcoids? And why ?
PCR-based screening of FNA for BPV-1/− 2 represents a valid method to improve the consistency and quality of sarcoid diagnosis.
FNA is a rapid and easily performed procedure. It allows for BPV detection in both ulcerated and non-ulcerated sarcoids and concurrently prevents false positive results from superficial contamination.
Cross-sectional comparison of superficial swab and fine-needle aspiration:
Improving the diagnostic workup of horses with sarcoids
Vet. J 2022
What is the expected overall response rate using 4 doses of ALVAC-fIL2 for sarcoid treatment ?
Tumor size decreased in 86% of the horses, and the median time to first response was 89 days. Adverse events were minimal and included transient focal inflammation in 2 horses.
ALVAC-fIL2, a feline interleukin-2 immunomodulator,
as a treatment for sarcoids in horses: A pilot study
JVIM 2022
What is the efficacy of oral and subcutaneous administration of mistletoe extract for the treatment of equine sarcoids ?
No statistically significant difference in the effectiveness of systemic mistletoe extract (PO and SC) versus placebo against equine sarcoids
A randomized placebo-controlled double-blinded study
comparing oral and subcutaneous administration of mistletoe
extract for the treatment of equine sarcoid disease
JVIM 2024
Which histological feature is associated with lower recurrence of equine sarcoids following surgical removal ?
Superficial inflammation was significantly associated with reduced odds of recurrence of equine sarcoids at their original surgical removal site.
It is noteworthy that treatments for equine sarcoids, such as the topical chemotherapeutic agents 5-fluorouracil and imiquimod, probably work by inducing ulceration and active inflammation.
Histological evidence of superficial inflammation is associated with lower
recurrence of equine sarcoids following surgical removal: A follow-up study
of 106 tumours in 64 horses
Vet. J. 2023
What are the cutaneous diseases associated with BPV and EcPV ?
BPV-1, 2 and 13 : equine sarcoids
Equus caballus PV-1 : oral warts of young horses
EcPV-2 : genital papillomas
EcPV-1 to 9 : aural plague
Equus asinus PV-1 to 3 : disease ?
Novel equid papillomavirus from domestic donkey
evj 2024
What is the safety and efficacy of strontium plesiotherapy for the treatment of equine sarcoids ?
Strontium plesiotherapy appears to be an effective and safe method of treating selected sarcoids (complete resolution in all 10 cases).
Longer term follow-up is required to determine the risk of recurrence of treated lesions.
Strontium plesiotherapy for the treatment of sarcoids in the horse
eve 2020
Which are the BPV associated with equine sarcoids ?
BPV-1, BPV-2, and BPV-13 (recently isolated in Brazil, but not in Austria)
Screening for bovine papillomavirus type 13 (BPV13) in a
European population of sarcoid- bearing equids
EVJ 2022
Which of the following statements accurately summarizes the findings and details from the study on Viscum album extract (VAE) treatment in horses with equine sarcoids (ES)?
A) The study demonstrated that oral VAE was significantly more effective than placebo and SC VAE, with a complete regression rate of over 40% in the oral VAE group and no cases of spontaneous regression in the placebo group.
B) The study found no statistically significant difference in the effectiveness of systemic VAE (either oral or SC) compared to placebo, with both routes of VAE administration showing similar complete or partial regression rates and a spontaneous regression observed in the placebo group.
C) Spontaneous regression was completely absent in both the placebo and VAE groups, and the study concluded that SC VAE injections led to significantly higher regression rates than oral VAE.
D) The study’s primary endpoint showed that horses treated with SC VAE had significantly higher rates of complete regression compared to those treated with oral VAE or placebo, with a statistically significant P-value of 0.01 confirming the superiority of SC administration.
Answer: B
A: INCORRECT The study found no statistically significant difference in effectiveness between oral VAE, SC VAE, and placebo, with a P-value of 0.336 indicating no statistical significance. Furthermore, spontaneous regression was observed in 2 horses from the placebo group, meaning the statement that there were “no cases of spontaneous regression in the placebo group” is also false.
B) Correct: Both oral VAE and SC VAE showed similar rates of complete or partial regression, but there was no statistically significant difference in effectiveness compared to placebo. Additionally, spontaneous regression was noted in the placebo group.
C)Incorrect: Spontaneous regression did occur, specifically in the placebo group (2 horses), and the study did not conclude that SC VAE was significantly better than oral VAE. Both treatments had similar clinical responses, with no statistical significance.
D) Incorrect: The P-value was 0.336, indicating that the difference was not statistically significant, and there was no superiority of SC VAE over oral VAE.
